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@article{1227578,
author = {Fulcher, N. and Derboven, E. and Valuchova, S. and Říha, Karel},
article_location = {BASEL},
article_number = {5},
doi = {http://dx.doi.org/10.1007/s00018-013-1469-z},
keywords = {Telomeres; Telomerase; Chromosomes; Genome evolution; DNA repair; Retrotransposons},
language = {eng},
issn = {1420-682X},
journal = {Cellular and molecular life sciences},
title = {If the cap fits, wear it: an overview of telomeric structures over evolution},
url = {http://download.springer.com/static/pdf/233/art%253A10.1007%252Fs00018-013-1469-z.pdf?auth66=1424688549_1693e66271e371331f99a2b7b64a52d7&ext=.pdf},
volume = {71},
year = {2014}
}
TY - JOUR
ID - 1227578
AU - Fulcher, N. - Derboven, E. - Valuchova, S. - Říha, Karel
PY - 2014
TI - If the cap fits, wear it: an overview of telomeric structures over evolution
JF - Cellular and molecular life sciences
VL - 71
IS - 5
SP - 847-865
EP - 847-865
PB - BIRKHAUSER VERLAG AG
SN - 1420682X
KW - Telomeres
KW - Telomerase
KW - Chromosomes
KW - Genome evolution
KW - DNA repair
KW - Retrotransposons
UR - http://download.springer.com/static/pdf/233/art%253A10.1007%252Fs00018-013-1469-z.pdf?auth66=1424688549_1693e66271e371331f99a2b7b64a52d7&ext=.pdf
L2 - http://download.springer.com/static/pdf/233/art%253A10.1007%252Fs00018-013-1469-z.pdf?auth66=1424688549_1693e66271e371331f99a2b7b64a52d7&ext=.pdf
N2 - Genome organization into linear chromosomes likely represents an important evolutionary innovation that has permitted the development of the sexual life cycle; this process has consequently advanced nuclear expansion and increased complexity of eukaryotic genomes. Chromosome linearity, however, poses a major challenge to the internal cellular machinery. The need to efficiently recognize and repair DNA double-strand breaks that occur as a consequence of DNA damage presents a constant threat to native chromosome ends known as telomeres. In this review, we present a comparative survey of various solutions to the end protection problem, maintaining an emphasis on DNA structure. This begins with telomeric structures derived from a subset of prokaryotes, mitochondria, and viruses, and will progress into the typical telomere structure exhibited by higher organisms containing TTAGG-like tandem sequences. We next examine non-canonical telomeres from Drosophila melanogaster, which comprise arrays of retrotransposons. Finally, we discuss telomeric structures in evolution and possible switches between canonical and non-canonical solutions to chromosome end protection.
ER -
FULCHER, N., E. DERBOVEN, S. VALUCHOVA a Karel ŘÍHA. If the cap fits, wear it: an overview of telomeric structures over evolution. \textit{Cellular and molecular life sciences}. BASEL: BIRKHAUSER VERLAG AG, roč.~71, č.~5, s.~847-865. ISSN~1420-682X. doi:10.1007/s00018-013-1469-z. 2014.
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