Nonsense-Mediated mRNA Decay Modulates Immune Receptor Levels
to Regulate Plant Antibacterial Defense

J 2014

Nonsense-Mediated mRNA Decay Modulates Immune Receptor Levels to Regulate Plant Antibacterial Defense

GLOGGNITZER, J., S. AKIMCHEVA, A. SRINIVASAN, B. KUSENDA, N. RIEHS et. al.

Basic information

Original name

Nonsense-Mediated mRNA Decay Modulates Immune Receptor Levels to Regulate Plant Antibacterial Defense

Authors

GLOGGNITZER, J. (40 Austria), S. AKIMCHEVA (40 Austria), A. SRINIVASAN (276 Germany), B. KUSENDA (40 Austria), N. RIEHS (40 Austria), H. STAMPFL (40 Austria), J. BAUTOR (276 Germany), B. DEKROUT (40 Austria), C. JONAK (40 Austria), J.M. JIMENEZ-GOMEZ (276 Germany), J.E. PARKER (276 Germany) and Karel ŘÍHA (203 Czech Republic, guarantor, belonging to the institution)

Edition

CELL HOST & MICROBE, CAMBRIDGE, CELL PRESS, 2014, 1931-3128

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

Genetics and molecular biology

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 12.328

RIV identification code

RIV/00216224:14740/14:00079177

Organization unit

Central European Institute of Technology

DOI

http://dx.doi.org/10.1016/j.chom.2014.08.010

UT WoS

000342057000014

Keywords in English

DISEASE RESISTANCE; GENE-EXPRESSION; ENCODING GENES; HUMAN-CELLS; ARABIDOPSIS; NMD; BINDING; GROWTH; UPF1; INHIBITION

Abstract

V originále

Nonsense-mediated mRNA decay (NMD) is a conserved eukaryotic RNA surveillance mechanism that degrades aberrant mRNAs. NMD impairment in Arabidopsis is linked to constitutive immune response activation and enhanced antibacterial resistance, but the underlying mechanisms are unknown. Here we show that NMD contributes to innate immunity in Arabidopsis by controlling the turnover of numerous TIR domain-containing, nucleotide-binding, leucine-rich repeat (TNL) immune receptor-encoding mRNAs. Autoimmunity resulting from NMD impairment depends on TNL signaling pathway components and can be triggered through deregulation of a single TNL gene, RPS6. Bacterial infection of plants causes host-programmed inhibition of NMD, leading to stabilization of NMD-regulated TNL transcripts. Conversely, constitutive NMD activity prevents TNL stabilization and impairs plant defense, demonstrating that host-regulated NMD contributes to disease resistance. Thus, NMD shapes plant innate immunity by controlling the threshold for activation of TNL resistance pathways.

Citovat

GLOGGNITZER, J., S. AKIMCHEVA, A. SRINIVASAN, B. KUSENDA, N. RIEHS, H. STAMPFL, J. BAUTOR, B. DEKROUT, C. JONAK, J.M. JIMENEZ-GOMEZ, J.E. PARKER and Karel ŘÍHA. Nonsense-Mediated mRNA Decay Modulates Immune Receptor Levels to Regulate Plant Antibacterial Defense. CELL HOST & MICROBE. CAMBRIDGE: CELL PRESS, 2014, vol. 16, No 3, p. 376-390. ISSN 1931-3128. Available from: https://dx.doi.org/10.1016/j.chom.2014.08.010.

@article{1227583,
   author = {Gloggnitzer, J. and Akimcheva, S. and Srinivasan, A. and Kusenda, B. and Riehs, N. and Stampfl, H. and Bautor, J. and Dekrout, B. and Jonak, C. and JimenezandGomez, J.M. and Parker, J.E. and Říha, Karel},
   article_location = {CAMBRIDGE},
   article_number = {3},
   doi = {http://dx.doi.org/10.1016/j.chom.2014.08.010},
   keywords = {DISEASE RESISTANCE; GENE-EXPRESSION; ENCODING GENES; HUMAN-CELLS; ARABIDOPSIS; NMD; BINDING; GROWTH; UPF1; INHIBITION},
   language = {eng},
   issn = {1931-3128},
   journal = {CELL HOST & MICROBE},
   title = {Nonsense-Mediated mRNA Decay Modulates Immune Receptor Levels to Regulate Plant Antibacterial Defense},
   url = {http://www.sciencedirect.com/science/article/pii/S1931312814003023},
   volume = {16},
   year = {2014}
}

TY  - JOUR
ID  - 1227583
AU  - Gloggnitzer, J. - Akimcheva, S. - Srinivasan, A. - Kusenda, B. - Riehs, N. - Stampfl, H. - Bautor, J. - Dekrout, B. - Jonak, C. - Jimenez-Gomez, J.M. - Parker, J.E. - Říha, Karel
PY  - 2014
TI  - Nonsense-Mediated mRNA Decay Modulates Immune Receptor Levels to Regulate Plant Antibacterial Defense
JF  - CELL HOST & MICROBE
VL  - 16
IS  - 3
SP  - 376-390
EP  - 376-390
PB  - CELL PRESS
SN  - 19313128
KW  - DISEASE RESISTANCE
KW  - GENE-EXPRESSION
KW  - ENCODING GENES
KW  - HUMAN-CELLS
KW  - ARABIDOPSIS
KW  - NMD
KW  - BINDING
KW  - GROWTH
KW  - UPF1
KW  - INHIBITION
UR  - http://www.sciencedirect.com/science/article/pii/S1931312814003023
L2  - http://www.sciencedirect.com/science/article/pii/S1931312814003023
N2  - Nonsense-mediated mRNA decay (NMD) is a conserved eukaryotic RNA surveillance mechanism that degrades aberrant mRNAs. NMD impairment in Arabidopsis is linked to constitutive immune response activation and enhanced antibacterial resistance, but the underlying mechanisms are unknown. Here we show that NMD contributes to innate immunity in Arabidopsis by controlling the turnover of numerous TIR domain-containing, nucleotide-binding, leucine-rich repeat (TNL) immune receptor-encoding mRNAs. Autoimmunity resulting from NMD impairment depends on TNL signaling pathway components and can be triggered through deregulation of a single TNL gene, RPS6. Bacterial infection of plants causes host-programmed inhibition of NMD, leading to stabilization of NMD-regulated TNL transcripts. Conversely, constitutive NMD activity prevents TNL stabilization and impairs plant defense, demonstrating that host-regulated NMD contributes to disease resistance. Thus, NMD shapes plant innate immunity by controlling the threshold for activation of TNL resistance pathways.
ER  -

GLOGGNITZER, J., S. AKIMCHEVA, A. SRINIVASAN, B. KUSENDA, N. RIEHS, H. STAMPFL, J. BAUTOR, B. DEKROUT, C. JONAK, J.M. JIMENEZ-GOMEZ, J.E. PARKER and Karel ŘÍHA. Nonsense-Mediated mRNA Decay Modulates Immune Receptor Levels to Regulate Plant Antibacterial Defense. \textit{CELL HOST \&{}amp; MICROBE}. CAMBRIDGE: CELL PRESS, 2014, vol.~16, No~3, p.~376-390. ISSN~1931-3128. Available from: https://dx.doi.org/10.1016/j.chom.2014.08.010.

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