GLOGGNITZER, J., S. AKIMCHEVA, A. SRINIVASAN, B. KUSENDA, N. RIEHS, H. STAMPFL, J. BAUTOR, B. DEKROUT, C. JONAK, J.M. JIMENEZ-GOMEZ, J.E. PARKER and Karel ŘÍHA. Nonsense-Mediated mRNA Decay Modulates Immune Receptor Levels to Regulate Plant Antibacterial Defense. CELL HOST & MICROBE. CAMBRIDGE: CELL PRESS, 2014, vol. 16, No 3, p. 376-390. ISSN 1931-3128. Available from: https://dx.doi.org/10.1016/j.chom.2014.08.010.
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Basic information
Original name Nonsense-Mediated mRNA Decay Modulates Immune Receptor Levels to Regulate Plant Antibacterial Defense
Authors GLOGGNITZER, J. (40 Austria), S. AKIMCHEVA (40 Austria), A. SRINIVASAN (276 Germany), B. KUSENDA (40 Austria), N. RIEHS (40 Austria), H. STAMPFL (40 Austria), J. BAUTOR (276 Germany), B. DEKROUT (40 Austria), C. JONAK (40 Austria), J.M. JIMENEZ-GOMEZ (276 Germany), J.E. PARKER (276 Germany) and Karel ŘÍHA (203 Czech Republic, guarantor, belonging to the institution).
Edition CELL HOST & MICROBE, CAMBRIDGE, CELL PRESS, 2014, 1931-3128.
Other information
Original language English
Type of outcome Article in a journal
Field of Study Genetics and molecular biology
Country of publisher United States of America
Confidentiality degree is not subject to a state or trade secret
WWW URL
Impact factor Impact factor: 12.328
RIV identification code RIV/00216224:14740/14:00079177
Organization unit Central European Institute of Technology
Doi http://dx.doi.org/10.1016/j.chom.2014.08.010
UT WoS 000342057000014
Keywords in English DISEASE RESISTANCE; GENE-EXPRESSION; ENCODING GENES; HUMAN-CELLS; ARABIDOPSIS; NMD; BINDING; GROWTH; UPF1; INHIBITION
Tags kontrola MP, MP, rivok
Tags International impact, Reviewed
Changed by Changed by: Martina Prášilová, učo 342282. Changed: 23/2/2015 12:04.
Abstract
Nonsense-mediated mRNA decay (NMD) is a conserved eukaryotic RNA surveillance mechanism that degrades aberrant mRNAs. NMD impairment in Arabidopsis is linked to constitutive immune response activation and enhanced antibacterial resistance, but the underlying mechanisms are unknown. Here we show that NMD contributes to innate immunity in Arabidopsis by controlling the turnover of numerous TIR domain-containing, nucleotide-binding, leucine-rich repeat (TNL) immune receptor-encoding mRNAs. Autoimmunity resulting from NMD impairment depends on TNL signaling pathway components and can be triggered through deregulation of a single TNL gene, RPS6. Bacterial infection of plants causes host-programmed inhibition of NMD, leading to stabilization of NMD-regulated TNL transcripts. Conversely, constitutive NMD activity prevents TNL stabilization and impairs plant defense, demonstrating that host-regulated NMD contributes to disease resistance. Thus, NMD shapes plant innate immunity by controlling the threshold for activation of TNL resistance pathways.
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