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@article{1227583, author = {Gloggnitzer, J. and Akimcheva, S. and Srinivasan, A. and Kusenda, B. and Riehs, N. and Stampfl, H. and Bautor, J. and Dekrout, B. and Jonak, C. and JimenezandGomez, J.M. and Parker, J.E. and Říha, Karel}, article_location = {CAMBRIDGE}, article_number = {3}, doi = {http://dx.doi.org/10.1016/j.chom.2014.08.010}, keywords = {DISEASE RESISTANCE; GENE-EXPRESSION; ENCODING GENES; HUMAN-CELLS; ARABIDOPSIS; NMD; BINDING; GROWTH; UPF1; INHIBITION}, language = {eng}, issn = {1931-3128}, journal = {CELL HOST & MICROBE}, title = {Nonsense-Mediated mRNA Decay Modulates Immune Receptor Levels to Regulate Plant Antibacterial Defense}, url = {http://www.sciencedirect.com/science/article/pii/S1931312814003023}, volume = {16}, year = {2014} }
TY - JOUR ID - 1227583 AU - Gloggnitzer, J. - Akimcheva, S. - Srinivasan, A. - Kusenda, B. - Riehs, N. - Stampfl, H. - Bautor, J. - Dekrout, B. - Jonak, C. - Jimenez-Gomez, J.M. - Parker, J.E. - Říha, Karel PY - 2014 TI - Nonsense-Mediated mRNA Decay Modulates Immune Receptor Levels to Regulate Plant Antibacterial Defense JF - CELL HOST & MICROBE VL - 16 IS - 3 SP - 376-390 EP - 376-390 PB - CELL PRESS SN - 19313128 KW - DISEASE RESISTANCE KW - GENE-EXPRESSION KW - ENCODING GENES KW - HUMAN-CELLS KW - ARABIDOPSIS KW - NMD KW - BINDING KW - GROWTH KW - UPF1 KW - INHIBITION UR - http://www.sciencedirect.com/science/article/pii/S1931312814003023 L2 - http://www.sciencedirect.com/science/article/pii/S1931312814003023 N2 - Nonsense-mediated mRNA decay (NMD) is a conserved eukaryotic RNA surveillance mechanism that degrades aberrant mRNAs. NMD impairment in Arabidopsis is linked to constitutive immune response activation and enhanced antibacterial resistance, but the underlying mechanisms are unknown. Here we show that NMD contributes to innate immunity in Arabidopsis by controlling the turnover of numerous TIR domain-containing, nucleotide-binding, leucine-rich repeat (TNL) immune receptor-encoding mRNAs. Autoimmunity resulting from NMD impairment depends on TNL signaling pathway components and can be triggered through deregulation of a single TNL gene, RPS6. Bacterial infection of plants causes host-programmed inhibition of NMD, leading to stabilization of NMD-regulated TNL transcripts. Conversely, constitutive NMD activity prevents TNL stabilization and impairs plant defense, demonstrating that host-regulated NMD contributes to disease resistance. Thus, NMD shapes plant innate immunity by controlling the threshold for activation of TNL resistance pathways. ER -
GLOGGNITZER, J., S. AKIMCHEVA, A. SRINIVASAN, B. KUSENDA, N. RIEHS, H. STAMPFL, J. BAUTOR, B. DEKROUT, C. JONAK, J.M. JIMENEZ-GOMEZ, J.E. PARKER and Karel ŘÍHA. Nonsense-Mediated mRNA Decay Modulates Immune Receptor Levels to Regulate Plant Antibacterial Defense. \textit{CELL HOST \&{}amp; MICROBE}. CAMBRIDGE: CELL PRESS, 2014, vol.~16, No~3, p.~376-390. ISSN~1931-3128. Available from: https://dx.doi.org/10.1016/j.chom.2014.08.010.
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