Truncated tau deregulates synaptic markers in rat model for human tauopathy

@article{1227675,
   author = {Jadhav, Santosh and Katina, Stanislav and Kovac, Andrej and Kazmerova, Zuzana and Novak, Michal and Zilka, Norbert},
   article_location = {Lausanne, Switzerland},
   article_number = {February},
   doi = {http://dx.doi.org/10.3389/fncel.2015.00024},
   keywords = {Alzheimer’s disease; truncated tau; phosphorylation; synaptic damage; tau mislocalization},
   language = {eng},
   issn = {1662-5102},
   journal = {Frontiers in Cellular Neuroscience},
   title = {Truncated tau deregulates synaptic markers in rat model for human tauopathy},
   url = {http://journal.frontiersin.org/article/10.3389/fncel.2015.00024/abstract},
   volume = {9},
   year = {2015}
}

TY  - JOUR
ID  - 1227675
AU  - Jadhav, Santosh - Katina, Stanislav - Kovac, Andrej - Kazmerova, Zuzana - Novak, Michal - Zilka, Norbert
PY  - 2015
TI  - Truncated tau deregulates synaptic markers in rat model for human tauopathy
JF  - Frontiers in Cellular Neuroscience
VL  - 9
IS  - February
SP  - 1-14
EP  - 1-14
PB  - Frontiers
SN  - 16625102
KW  - Alzheimer’s disease
KW  - truncated tau
KW  - phosphorylation
KW  - synaptic damage
KW  - tau mislocalization
UR  - http://journal.frontiersin.org/article/10.3389/fncel.2015.00024/abstract
L2  - http://journal.frontiersin.org/article/10.3389/fncel.2015.00024/abstract
N2  - Synaptic failure and neurofibrillary degeneration are two major neuropathological substrates of cognitive dysfunction in Alzheimer’s disease (AD). Only a few studies have demonstrated a direct relationship between these two AD hallmarks. To investigate tau mediated synaptic injury we used rat model of tauopathy that develops extensive neurofibrillary pathology in the cortex. Using fractionation of cortical synapses, we identified an increase in endogenous rat tau isoforms in presynaptic compartment, and their mis-sorting to the postsynaptic density (PSD). Truncated transgenic tau was distributed in both compartments exhibiting specific phospho-pattern that was characteristic for each synaptic compartment. In the presynaptic compartment, truncated tau was associated with impairment of dynamic stability of microtubules which could be responsible for reduction of synaptic vesicles. In the PSD, truncated tau lowered the levels of neurofilaments. Truncated tau also significantly decreased the synaptic levels of AB40 but not AB42. These data show that truncated tau differentially deregulates synaptic proteome in pre- and postsynaptic compartments. Importantly, we show that alteration of AB can arise downstream of truncated tau pathology.
ER  - 

JADHAV, Santosh, Stanislav KATINA, Andrej KOVAC, Zuzana KAZMEROVA, Michal NOVAK and Norbert ZILKA. Truncated tau deregulates synaptic markers in rat model for human tauopathy. \textit{Frontiers in Cellular Neuroscience}. Lausanne, Switzerland: Frontiers, 2015, vol.~9, February, p.~1-14. ISSN~1662-5102. Available from: https://dx.doi.org/10.3389/fncel.2015.00024.