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@article{1228894, author = {Vlček, Přemysl and Bob, Petr and Raboch, Jiří}, article_location = {ALBANY}, article_number = {July}, doi = {http://dx.doi.org/10.2147/NDT.S64219}, keywords = {event-related potential; information overload; inhibition; P50 wave; schizophrenia; splitting}, language = {eng}, issn = {1178-2021}, journal = {NEUROPSYCHIATRIC DISEASE AND TREATMENT}, title = {Sensory disturbances, inhibitory deficits, and the P50 wave in schizophrenia}, url = {http://www.dovepress.com/sensory-disturbances-inhibitory-deficits-and-the-p50-wave-in-schizophr-peer-reviewed-article-NDT}, volume = {10}, year = {2014} }
TY - JOUR ID - 1228894 AU - Vlček, Přemysl - Bob, Petr - Raboch, Jiří PY - 2014 TI - Sensory disturbances, inhibitory deficits, and the P50 wave in schizophrenia JF - NEUROPSYCHIATRIC DISEASE AND TREATMENT VL - 10 IS - July SP - 1309-1315 EP - 1309-1315 PB - DOVE MEDICAL PRESS LTD SN - 11782021 KW - event-related potential KW - information overload KW - inhibition KW - P50 wave KW - schizophrenia KW - splitting UR - http://www.dovepress.com/sensory-disturbances-inhibitory-deficits-and-the-p50-wave-in-schizophr-peer-reviewed-article-NDT L2 - http://www.dovepress.com/sensory-disturbances-inhibitory-deficits-and-the-p50-wave-in-schizophr-peer-reviewed-article-NDT N2 - Sensory gating disturbances in schizophrenia are often described as an inability to filter redundant sensory stimuli that typically manifest as inability to gate neuronal responses related to the P50 wave, characterizing a decreased ability of the brain to inhibit various responses to insignificant stimuli. It implicates various deficits of perceptual and attentional functions, and this inability to inhibit, or "gate", irrelevant sensory inputs leads to sensory and information overload that also may result in neuronal hyperexcitability related to disturbances of habituation mechanisms. These findings seem to be particularly important in the context of modern electrophysiological and neuroimaging data suggesting that the filtering deficits in schizophrenia are likely related to deficits in the integrity of connections between various brain areas. As a consequence, this brain disintegration produces disconnection of information, disrupted binding, and disintegration of consciousness that in terms of modern neuroscience could connect original Bleuler's concept of "split mind" with research of neural information integration. ER -
VLČEK, Přemysl, Petr BOB and Jiří RABOCH. Sensory disturbances, inhibitory deficits, and the P50 wave in schizophrenia. \textit{NEUROPSYCHIATRIC DISEASE AND TREATMENT}. ALBANY: DOVE MEDICAL PRESS LTD, 2014, vol.~10, July, p.~1309-1315. ISSN~1178-2021. Available from: https://dx.doi.org/10.2147/NDT.S64219.
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