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@article{1228894,
author = {Vlček, Přemysl and Bob, Petr and Raboch, Jiří},
article_location = {ALBANY},
article_number = {July},
doi = {http://dx.doi.org/10.2147/NDT.S64219},
keywords = {event-related potential; information overload; inhibition; P50 wave; schizophrenia; splitting},
language = {eng},
issn = {1178-2021},
journal = {NEUROPSYCHIATRIC DISEASE AND TREATMENT},
title = {Sensory disturbances, inhibitory deficits, and the P50 wave in schizophrenia},
url = {http://www.dovepress.com/sensory-disturbances-inhibitory-deficits-and-the-p50-wave-in-schizophr-peer-reviewed-article-NDT},
volume = {10},
year = {2014}
}
TY - JOUR
ID - 1228894
AU - Vlček, Přemysl - Bob, Petr - Raboch, Jiří
PY - 2014
TI - Sensory disturbances, inhibitory deficits, and the P50 wave in schizophrenia
JF - NEUROPSYCHIATRIC DISEASE AND TREATMENT
VL - 10
IS - July
SP - 1309-1315
EP - 1309-1315
PB - DOVE MEDICAL PRESS LTD
SN - 11782021
KW - event-related potential
KW - information overload
KW - inhibition
KW - P50 wave
KW - schizophrenia
KW - splitting
UR - http://www.dovepress.com/sensory-disturbances-inhibitory-deficits-and-the-p50-wave-in-schizophr-peer-reviewed-article-NDT
L2 - http://www.dovepress.com/sensory-disturbances-inhibitory-deficits-and-the-p50-wave-in-schizophr-peer-reviewed-article-NDT
N2 - Sensory gating disturbances in schizophrenia are often described as an inability to filter redundant sensory stimuli that typically manifest as inability to gate neuronal responses related to the P50 wave, characterizing a decreased ability of the brain to inhibit various responses to insignificant stimuli. It implicates various deficits of perceptual and attentional functions, and this inability to inhibit, or "gate", irrelevant sensory inputs leads to sensory and information overload that also may result in neuronal hyperexcitability related to disturbances of habituation mechanisms. These findings seem to be particularly important in the context of modern electrophysiological and neuroimaging data suggesting that the filtering deficits in schizophrenia are likely related to deficits in the integrity of connections between various brain areas. As a consequence, this brain disintegration produces disconnection of information, disrupted binding, and disintegration of consciousness that in terms of modern neuroscience could connect original Bleuler's concept of "split mind" with research of neural information integration.
ER -
VLČEK, Přemysl, Petr BOB and Jiří RABOCH. Sensory disturbances, inhibitory deficits, and the P50 wave in schizophrenia. \textit{NEUROPSYCHIATRIC DISEASE AND TREATMENT}. ALBANY: DOVE MEDICAL PRESS LTD, 2014, vol.~10, July, p.~1309-1315. ISSN~1178-2021. Available from: https://dx.doi.org/10.2147/NDT.S64219.
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