BEŠŠE, Lenka, Lenka SEDLAŘÍKOVÁ, Fedor KRYUKOV, Jana NEKVINDOVA, Lenka RADOVÁ, Martina ALMAŠI, Jana PELCOVA, Jiri MINARIK, Tomas PIKA, Zuzana PIKALOVA, Vlastimil SCUDLA, Marta KREJČÍ, Zdeněk ADAM, Luděk POUR, Roman HÁJEK and Sabina ŠEVČÍKOVÁ. Combination of serum microRNA-320a and microRNA-320b as a marker for Waldenström macroglobulinemia. American Journal of Hematology. Hoboken, USA: WILEY-BLACKWELL, 2015, vol. 90, No 3, p. "E51"-"E52", 2 pp. ISSN 0361-8609. doi:10.1002/ajh.23910.
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Basic information
Original name Combination of serum microRNA-320a and microRNA-320b as a marker for Waldenström macroglobulinemia
Authors BEŠŠE, Lenka (203 Czech Republic, belonging to the institution), Lenka SEDLAŘÍKOVÁ (203 Czech Republic, belonging to the institution), Fedor KRYUKOV (643 Russian Federation, belonging to the institution), Jana NEKVINDOVA (203 Czech Republic), Lenka RADOVÁ (203 Czech Republic, belonging to the institution), Martina ALMAŠI (203 Czech Republic, belonging to the institution), Jana PELCOVA (203 Czech Republic), Jiri MINARIK (203 Czech Republic), Tomas PIKA (203 Czech Republic), Zuzana PIKALOVA (203 Czech Republic), Vlastimil SCUDLA (203 Czech Republic), Marta KREJČÍ (203 Czech Republic), Zdeněk ADAM (203 Czech Republic), Luděk POUR (203 Czech Republic), Roman HÁJEK (203 Czech Republic, belonging to the institution) and Sabina ŠEVČÍKOVÁ (203 Czech Republic, guarantor, belonging to the institution).
Edition American Journal of Hematology, Hoboken, USA, WILEY-BLACKWELL, 2015, 0361-8609.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30200 3.2 Clinical medicine
Country of publisher United States of America
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 5.000
RIV identification code RIV/00216224:14110/15:00087435
Organization unit Faculty of Medicine
Doi http://dx.doi.org/10.1002/ajh.23910
UT WoS 000349889300006
Keywords in English microRNA-320a; microRNA-320b; Waldenström macroglobulinemia
Tags EL OK, podil
Tags International impact, Reviewed
Changed by Changed by: Ing. Mgr. Věra Pospíšilíková, učo 9005. Changed: 8. 4. 2015 12:58.
Abstract
IgM monoclonal gammopathies are a group of diseases characterized by increased level of IgM immunoglobulin produced by one clone of B cells. These diseases range trom benign (monoclonal gammopathy ot undetermined significance, MGUS) to malignant, such as Waldenstrom macroglobulinemia (WM) or to a lesser extent multiple myeloma (MM) [1,2]. The criteria that differentiate WM from IgM-MGUS are based on the extent of bone marrow (BM) involvement, amount of serum concentration of the M-proicin, presence or absence of symptomatic disease or more recently, MYD88 (L265P) or CXCR4 mutations [3-6]. Despite that, new criteria for the differential diagnosis between these conditions are still needed, circulating microRNAs (miRNAs) being one of them. Circulating miRNAs are present in different body fluids; they reflect physiological or pathologi cal conditions and can be used tor patient classification [7,8]. Thus, we aimed to investigate the ability of serum miRNAs to distinguish WM from IgM-MGUS as well as IgM-MM patients and healthy donors (HD).
Links
NT13190, research and development projectName: Molekulární charakteristika centrozomálních abnormalit a jejich prognostický význam pro pacienty s mnohočetným myelomem
Investor: Ministry of Health of the CR
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