| PANTŮČEK, Roman, Martin BENEŠÍK, Marian VARGA, Ivana MAŠLAŇOVÁ, Marek MOŠA, Josef BOŠTÍK a Jiří DOŠKAŘ. Characterization of host-range mutations in genomes of Staphylococcus Twortlikeviruses. Russian Journal of Infection and Immunity. Sankt Peterburg: InformMed, 2014, roč. 4, S1, s. 49-50. ISSN 2220-7619. |
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@article{1229242,
author = {Pantůček, Roman and Benešík, Martin and Varga, Marian and Mašlaňová, Ivana and Moša, Marek and Boštík, Josef and Doškař, Jiří},
article_location = {Sankt Peterburg},
article_number = {S1},
keywords = {bacteriophage therapy; Staphylococcus aureus; Twortlikevirus},
language = {eng},
issn = {2220-7619},
journal = {Russian Journal of Infection and Immunity},
title = {Characterization of host-range mutations in genomes of Staphylococcus Twortlikeviruses},
url = {http://iimmun.ru/index.php/iimm},
volume = {4},
year = {2014}
}
TY - JOUR
ID - 1229242
AU - Pantůček, Roman - Benešík, Martin - Varga, Marian - Mašlaňová, Ivana - Moša, Marek - Boštík, Josef - Doškař, Jiří
PY - 2014
TI - Characterization of host-range mutations in genomes of Staphylococcus Twortlikeviruses
JF - Russian Journal of Infection and Immunity
VL - 4
IS - S1
SP - 49-50
EP - 49-50
PB - InformMed
SN - 22207619
KW - bacteriophage therapy
KW - Staphylococcus aureus
KW - Twortlikevirus
UR - http://iimmun.ru/index.php/iimm
N2 - The emergence and alarming increase of multiresistant strains of Staphylococcus aureus emphasizes the need for new and innovative antimicrobial strategies. Polyvalent bacteriophages from the family Myoviridae, sub-family Spounavirinae of genus Twort-like phages that infect S. aureus have potential for use in phage therapy. In this study we characterized genomic sequences of the polyvalent staphylococcal phage 812 and its spontaneous host-range mutants selected on non-susceptible S. aureus strains. The wild type phage was shown to lyse up to 65%, whereas host-range mutants up to 95% of S. aureus strains under study. Genomic DNAs of five phages were sequenced using 454 Genome Sequencer Junior (Roche). Bacteriophage DNA sequences were assembled by software GS De novo Assembler and GS Reference Mapper (Roche). Genome of phage K was chosen as the reference.
ER -
PANTŮČEK, Roman, Martin BENEŠÍK, Marian VARGA, Ivana MAŠLAŇOVÁ, Marek MOŠA, Josef BOŠTÍK a Jiří DOŠKAŘ. Characterization of host-range mutations in genomes of Staphylococcus Twortlikeviruses. \textit{Russian Journal of Infection and Immunity}. Sankt Peterburg: InformMed, 2014, roč.~4, S1, s.~49-50. ISSN~2220-7619.
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