J 2015

Hybrid therapy in the management of atrial fibrillation

STÁREK, Zdeněk, František LEHAR, Jiří JEŽ, Jiří WOLF, Miroslav NOVÁK et. al.

Basic information

Original name

Hybrid therapy in the management of atrial fibrillation

Authors

STÁREK, Zdeněk (203 Czech Republic, guarantor, belonging to the institution), František LEHAR (203 Czech Republic, belonging to the institution), Jiří JEŽ (203 Czech Republic, belonging to the institution), Jiří WOLF (203 Czech Republic, belonging to the institution) and Miroslav NOVÁK (203 Czech Republic, belonging to the institution)

Edition

Current Cardiology Reviews, San Francisco, Bentham Science Publishers B.V. 2015, 1573-403X

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30201 Cardiac and Cardiovascular systems

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

RIV identification code

RIV/00216224:14110/15:00082500

Organization unit

Faculty of Medicine

UT WoS

000212845800011

Keywords in English

Atrial fibrillation; catheter ablation of arrhythmias; pharmacological antiarrhythmic therapy; hybrid therapy

Tags

Tags

International impact, Reviewed
Změněno: 2/3/2016 12:24, Ing. Mgr. Věra Pospíšilíková

Abstract

V originále

Atrial fibrillation is the most common sustained arrhythmia. Because of the sub-optimal outcomes and associated risks of medical therapy as well as the recent advances in non-pharmacologic strategies, a multitude of combined (hybrid) algorithms have been introduced that improve efficacy of standalone therapies while maintaining a high safety profile. Antiarrhythmic administration enhances success rate of electrical cardioversion. Catheter ablation of antiarrhythmic drug-induced typical atrial flutter may prevent recurrent atrial fibrillation. Through simple ablation in the right atrium, suppression of atrial fibrillation may be achieved in patients with previously ineffective antiarrhythmic therapy. Efficacy of complex catheter ablation in the left atrium is improved with antiarrhythmic drugs. Catheter ablation followed by permanent pacemaker implantation is an effective and safe treatment option for selected patients. Additional strategies include pacing therapies such as atrial pacing with permanent pacemakers, preventive pacing algorithms, and/or implantable dual-chamber defibrillators are available. Modern hybrid strategies combining both epicardial and endocardial approaches in order to create a complex set of radiofrequency lesions in the left atrium have demonstrated a high rate of success and warrant further research. Hybrid therapy for atrial fibrillation reviews history of development of non-pharmacological treatment strategies and outlines avenues of ongoing research in this field.