Electrochemistry of Nonconjugated Proteins and Glycoproteins.
Toward Sensors for Biomedicine and Glycomics

J 2015

Electrochemistry of Nonconjugated Proteins and Glycoproteins. Toward Sensors for Biomedicine and Glycomics

PALEČEK, Emil, Ján TKÁČ, Martin BARTOŠÍK, Tomáš BERTÓK, Veronika OSTATNÁ et. al.

Basic information

Original name

Electrochemistry of Nonconjugated Proteins and Glycoproteins. Toward Sensors for Biomedicine and Glycomics

Name in Czech

Elektrochemie nekonjugovaných proteinů a glykoproteinů. K sensorům pro biomedicínu a glykomiku.

Authors

PALEČEK, Emil (203 Czech Republic), Ján TKÁČ (703 Slovakia), Martin BARTOŠÍK (703 Slovakia), Tomáš BERTÓK (703 Slovakia), Veronika OSTATNÁ (703 Slovakia) and Jan PALEČEK (203 Czech Republic, guarantor, belonging to the institution)

Edition

Chemical Reviews, Washington D.C. American Chemical Society, 2015, 0009-2665

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

10405 Electrochemistry

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 37.369

RIV identification code

RIV/00216224:14740/15:00080704

Organization unit

Central European Institute of Technology

DOI

http://dx.doi.org/10.1021/cr500279h

UT WoS

000351187400001

Keywords in English

Electrochemistry; Proteins; Glycoproteins; Sensors

Abstract

V originále

In this review, we wish to show that in the recent years a significant progress was done in the EC analysis of practically all proteins, based on electroactivity of amino acid (aa) residues in proteins. Also electrochemistry of polysaccharides, oligosaccharides and glycoproteins greatly advanced in creating important steps for its larger application in the glycoprotein research. In recent decades, a great effort was devoted to the discovery and application of biomarkers for analysis of different diseases, including cancer. In the following paragraphs, special attention will be paid (i) to intrinsic electroactivity of peptides and proteins, including the sensitivity to changes in protein 3D structures, as well as to recent advances in EC investigations of DNA-protein interactions, (ii) to intrinsic electroactivity of glycans and polysaccharides, advances in EC detection of lectin-glycoprotein interactions and to introduction of electroactive labels to polysaccharides and glycans and finally (iii) to EC detection of protein biomarkers, based predominantly on application of antibodies in immunoassays, nucleic acid and peptide aptamers for construction of aptasensors, and lectin biosensors for detection of glycoprotein biomarkers.

Links

ED1.1.00/02.0068, research and development project

Name: CEITEC - central european institute of technology

GA13-00774S, research and development project

Name: Úloha proteinů Nse, podjednotek komplexu SMC5/6, v procesech stabilizujících pozastavené replikační vidlice

Investor: Czech Science Foundation

Citovat

PALEČEK, Emil, Ján TKÁČ, Martin BARTOŠÍK, Tomáš BERTÓK, Veronika OSTATNÁ and Jan PALEČEK. Electrochemistry of Nonconjugated Proteins and Glycoproteins. Toward Sensors for Biomedicine and Glycomics. Chemical Reviews. Washington D.C.: American Chemical Society, 2015, vol. 115, No 5, p. 2045-2108. ISSN 0009-2665. Available from: https://dx.doi.org/10.1021/cr500279h.

@article{1230071,
   author = {Paleček, Emil and Tkáč, Ján and Bartošík, Martin and Bertók, Tomáš and Ostatná, Veronika and Paleček, Jan},
   article_location = {Washington D.C.},
   article_number = {5},
   doi = {http://dx.doi.org/10.1021/cr500279h},
   keywords = {Electrochemistry; Proteins; Glycoproteins; Sensors},
   language = {eng},
   issn = {0009-2665},
   journal = {Chemical Reviews},
   title = {Electrochemistry of Nonconjugated Proteins and Glycoproteins. Toward Sensors for Biomedicine and Glycomics},
   url = {http://pubs.acs.org/doi/pdf/10.1021/cr500279h},
   volume = {115},
   year = {2015}
}

TY  - JOUR
ID  - 1230071
AU  - Paleček, Emil - Tkáč, Ján - Bartošík, Martin - Bertók, Tomáš - Ostatná, Veronika - Paleček, Jan
PY  - 2015
TI  - Electrochemistry of Nonconjugated Proteins and Glycoproteins. Toward Sensors for Biomedicine and Glycomics
JF  - Chemical Reviews
VL  - 115
IS  - 5
SP  - 2045-2108
EP  - 2045-2108
PB  - American Chemical Society
SN  - 00092665
KW  - Electrochemistry
KW  - Proteins
KW  - Glycoproteins
KW  - Sensors
UR  - http://pubs.acs.org/doi/pdf/10.1021/cr500279h
L2  - http://pubs.acs.org/doi/pdf/10.1021/cr500279h
N2  - In this review, we wish to show that in the recent years a significant progress was done in the EC analysis of practically all proteins, based on electroactivity of amino acid (aa) residues in proteins. Also electrochemistry of polysaccharides, oligosaccharides and glycoproteins greatly advanced in creating important steps for its larger application in the glycoprotein research. In recent decades, a great effort was devoted to the discovery and application of biomarkers for analysis of different diseases, including cancer. In the following paragraphs, special attention will be paid (i) to intrinsic electroactivity of peptides and proteins, including the sensitivity to changes in protein 3D structures, as well as to recent advances in EC investigations of DNA-protein interactions, (ii) to intrinsic electroactivity of glycans and polysaccharides, advances in EC detection of lectin-glycoprotein interactions and to introduction of electroactive labels to polysaccharides and glycans and finally (iii) to EC detection of protein biomarkers, based predominantly on application of antibodies in immunoassays, nucleic acid and peptide aptamers for construction of aptasensors, and lectin biosensors for detection of glycoprotein biomarkers.
ER  -

PALEČEK, Emil, Ján TKÁČ, Martin BARTOŠÍK, Tomáš BERTÓK, Veronika OSTATNÁ and Jan PALEČEK. Electrochemistry of Nonconjugated Proteins and Glycoproteins. Toward Sensors for Biomedicine and Glycomics. \textit{Chemical Reviews}. Washington D.C.: American Chemical Society, 2015, vol.~115, No~5, p.~2045-2108. ISSN~0009-2665. Available from: https://dx.doi.org/10.1021/cr500279h.

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