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@article{1230107, author = {Bona, Mirco Dalla and Zounková, Radka and Merlanti, Roberta and Bláha, Luděk and De Liguoro, Marco}, article_location = {SAN DIEGO (USA)}, article_number = {MARCH}, doi = {http://dx.doi.org/10.1016/j.ecoenv.2014.11.018}, keywords = {Daphnia magna; Fluoroquinolones; Trimethoprim; Transgenerational toxicity}, language = {eng}, issn = {0147-6513}, journal = {Ecotoxicology and Environmental Safety}, title = {Effects of enrofloxacin, ciprofloxacin, and trimethoprim on two generations of Daphnia magna}, url = {http://www.sciencedirect.com/science/article/pii/S0147651314005302}, volume = {113}, year = {2015} }
TY - JOUR ID - 1230107 AU - Bona, Mirco Dalla - Zounková, Radka - Merlanti, Roberta - Bláha, Luděk - De Liguoro, Marco PY - 2015 TI - Effects of enrofloxacin, ciprofloxacin, and trimethoprim on two generations of Daphnia magna JF - Ecotoxicology and Environmental Safety VL - 113 IS - MARCH SP - 152-158 EP - 152-158 PB - Academic Press SN - 01476513 KW - Daphnia magna KW - Fluoroquinolones KW - Trimethoprim KW - Transgenerational toxicity UR - http://www.sciencedirect.com/science/article/pii/S0147651314005302 L2 - http://www.sciencedirect.com/science/article/pii/S0147651314005302 N2 - Multigenerational tests on Daphnia magna were performed exposing two subsequent generation to enrofloxacin (EFX) and its metabolite ciprofloxacin (CPX), and to trimethoprim (TMP). Mortality rate of 100% and 50% was detected in F0 at concentrations of >= 13 mg L-1 (EFX) and 50 mg L-1 (TMP), respectively. In F1 with respect to FO, both for growth and reproduction, a worsening trend of the response with EFX, a similar response with CPX and an attenuating trend with TMP was observed. Furthermore, the lowest EC20 for reproduction inhibition (1.3 mg L-1) was calculated for F1 exposed to EFX. However, other experimentations, longer and more complex, are necessary in order to confirm that EFX is more hazardous to daphnids than CPX and TMP. EC50 measured for the three assayed antibacterials were in the 6.5-37 mg L-1 range therefore environmental unrealistic, except in case of exceptional contaminations that may occur in relation to poorly controlled wastewaters from pharmaceutical factories or excessive use of prophylactic treatments in aquaculture. ER -
BONA, Mirco Dalla, Radka ZOUNKOVÁ, Roberta MERLANTI, Luděk BLÁHA and Marco DE LIGUORO. Effects of enrofloxacin, ciprofloxacin, and trimethoprim on two generations of Daphnia magna. \textit{Ecotoxicology and Environmental Safety}. SAN DIEGO (USA): Academic Press, 2015, vol.~113, MARCH, p.~152-158. ISSN~0147-6513. Available from: https://dx.doi.org/10.1016/j.ecoenv.2014.11.018.
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