DOLEŽALOVÁ, Dáša, Marek MRÁZ and Aleš HAMPL. MicroRNAs in Embryonic Stem Cells. In Chandan K. Sen. MicroRNA in regenerative medicine. London: Elsevier, 2015. p. 183-212. ISBN 978-0-12-405544-5. doi:10.1016/B978-0-12-405544-5.00007-1.
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Basic information
Original name MicroRNAs in Embryonic Stem Cells
Authors DOLEŽALOVÁ, Dáša (703 Slovakia, belonging to the institution), Marek MRÁZ (203 Czech Republic, belonging to the institution) and Aleš HAMPL (203 Czech Republic, guarantor, belonging to the institution).
Edition London, MicroRNA in regenerative medicine, p. 183-212, 30 pp. 2015.
Publisher Elsevier
Other information
Original language English
Type of outcome Chapter(s) of a specialized book
Field of Study Genetics and molecular biology
Country of publisher United Kingdom of Great Britain and Northern Ireland
Confidentiality degree is not subject to a state or trade secret
Publication form printed version "print"
RIV identification code RIV/00216224:14110/15:00082538
Organization unit Faculty of Medicine
ISBN 978-0-12-405544-5
Doi http://dx.doi.org/10.1016/B978-0-12-405544-5.00007-1
Keywords in English Adult stem cells; Cellular reprogramming; Human embryonic stem cells; Induced pluripotent stem cells; Pluripotency; Self-renewal
Tags EL OK, podil
Changed by Changed by: Ing. Mgr. Věra Pospíšilíková, učo 9005. Changed: 15. 12. 2015 08:53.
Abstract
Stem cell research began in the 1950s with the study of teratocarcinomas. Stevens and Little determined that these malignant germ-cell tumors comprise undifferentiated cell components (so-called embryonal carcinoma cells, or EC cells) that have the ability to form entirely new teratocarcinomas upon transplantation into experimental animals. In 1964, Lewis Kleinsmith and Barry Pierce demonstrated that a single EC cell is capable of multilineage differentiation as well as unlimited self-renewal—the two key characteristics of stem cells. Later, mouse EC cell lines that can be stably propagated in vitro were established, and several EC cell lines were shown to form chimeras upon injection into mouse blastocysts. Naturally, similar developmental properties of EC cells and early embryonic cells led to a search for a karyotypically stable counterpart of these cells. In the early 1980s, two groups simultaneously introduced the first pluripotent mouse embryonic stem cells to the scientific community.
Links
4SGA8684, interní kód MUName: The role of microRNAs in the biology of B cell leukemias and lymphomas (Acronym: miRNA in CLL)
Investor: South-Moravian Region
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