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@article{1230817,
author = {Mauro, Di E. and Saladino, R. and Trifonov, Eduard Nikolajevič},
article_location = {PHILADELPHIA},
article_number = {4},
doi = {http://dx.doi.org/10.1080/07391102.2013.783509},
keywords = {origin of life; simplissimus; RNA replicator; abiotic start; self-replication; border chemistry; life; formamide reactions},
language = {eng},
issn = {0739-1102},
journal = {JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS},
title = {The path to life's origins. Remaining hurdles},
url = {http://www.tandfonline.com/doi/pdf/10.1080/07391102.2013.783509#.VQlPoOFFrs4},
volume = {32},
year = {2014}
}
TY - JOUR
ID - 1230817
AU - Mauro, Di E. - Saladino, R. - Trifonov, Eduard Nikolajevič
PY - 2014
TI - The path to life's origins. Remaining hurdles
JF - JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
VL - 32
IS - 4
SP - 512-522
EP - 512-522
PB - TAYLOR & FRANCIS INC
SN - 07391102
KW - origin of life
KW - simplissimus
KW - RNA replicator
KW - abiotic start
KW - self-replication
KW - border chemistry
KW - life
KW - formamide reactions
UR - http://www.tandfonline.com/doi/pdf/10.1080/07391102.2013.783509#.VQlPoOFFrs4
L2 - http://www.tandfonline.com/doi/pdf/10.1080/07391102.2013.783509#.VQlPoOFFrs4
N2 - Recent progress in abiotic syntheses, especially self-catalytic syntheses, as well as theoretical breakthroughs such as reconstruction of events of early molecular evolution and tracing repeat expansions in contemporary genomes, converge to a rather simple possible scenario of origin of life, notwithstanding the enormity of the problem. The scenario includes self-replicating RNA duplexes, supplemented by monomers and high-energy compounds that, as demonstrated or assumed, can all be synthesized abiotically. The self-replication would proceed with occasional mutational changes, propagated in later cycles. This audacious, as it may seem, walk toward the life origin already involves many laboratories, each exploring its own scenario. The one suggested in this outline seems to the authors well justified to engage in, while bypassing few steps to deal with later.
ER -
MAURO, Di E., R. SALADINO a Eduard Nikolajevič TRIFONOV. The path to life's origins. Remaining hurdles. \textit{JOURNAL OF BIOMOLECULAR STRUCTURE \&{}amp; DYNAMICS}. PHILADELPHIA: TAYLOR \&{}amp; FRANCIS INC, roč.~32, č.~4, s.~512-522. ISSN~0739-1102. doi:10.1080/07391102.2013.783509. 2014.
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