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@article{1230817, author = {Mauro, Di E. and Saladino, R. and Trifonov, Eduard Nikolajevič}, article_location = {PHILADELPHIA}, article_number = {4}, doi = {http://dx.doi.org/10.1080/07391102.2013.783509}, keywords = {origin of life; simplissimus; RNA replicator; abiotic start; self-replication; border chemistry; life; formamide reactions}, language = {eng}, issn = {0739-1102}, journal = {JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS}, title = {The path to life's origins. Remaining hurdles}, url = {http://www.tandfonline.com/doi/pdf/10.1080/07391102.2013.783509#.VQlPoOFFrs4}, volume = {32}, year = {2014} }
TY - JOUR ID - 1230817 AU - Mauro, Di E. - Saladino, R. - Trifonov, Eduard Nikolajevič PY - 2014 TI - The path to life's origins. Remaining hurdles JF - JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS VL - 32 IS - 4 SP - 512-522 EP - 512-522 PB - TAYLOR & FRANCIS INC SN - 07391102 KW - origin of life KW - simplissimus KW - RNA replicator KW - abiotic start KW - self-replication KW - border chemistry KW - life KW - formamide reactions UR - http://www.tandfonline.com/doi/pdf/10.1080/07391102.2013.783509#.VQlPoOFFrs4 L2 - http://www.tandfonline.com/doi/pdf/10.1080/07391102.2013.783509#.VQlPoOFFrs4 N2 - Recent progress in abiotic syntheses, especially self-catalytic syntheses, as well as theoretical breakthroughs such as reconstruction of events of early molecular evolution and tracing repeat expansions in contemporary genomes, converge to a rather simple possible scenario of origin of life, notwithstanding the enormity of the problem. The scenario includes self-replicating RNA duplexes, supplemented by monomers and high-energy compounds that, as demonstrated or assumed, can all be synthesized abiotically. The self-replication would proceed with occasional mutational changes, propagated in later cycles. This audacious, as it may seem, walk toward the life origin already involves many laboratories, each exploring its own scenario. The one suggested in this outline seems to the authors well justified to engage in, while bypassing few steps to deal with later. ER -
MAURO, Di E., R. SALADINO and Eduard Nikolajevič TRIFONOV. The path to life's origins. Remaining hurdles. \textit{JOURNAL OF BIOMOLECULAR STRUCTURE \&{}amp; DYNAMICS}. PHILADELPHIA: TAYLOR \&{}amp; FRANCIS INC, 2014, vol.~32, No~4, p.~512-522. ISSN~0739-1102. Available from: https://dx.doi.org/10.1080/07391102.2013.783509.
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