| BIENERTOVÁ VAŠKŮ, Julie, Filip ZLÁMAL, Josef TOMANDL, Zuzana HODICKÁ, Jan NOVÁK, Zbyněk ŠPLÍCHAL, Pavel VENTRUBA, Vojtěch THON and Anna VAŠKŮ. The presence of B-cell activating factor (BAFF) in umbilical cord blood in both healthy and pre-eclamptic pregnancies and in human breast milk. Journal of Reproductive Immunology. Clare: Elsevier Ireland Ltd., 2015, vol. 109, JUN 2015, p. 89-93. ISSN 0165-0378. Available from: https://dx.doi.org/10.1016/j.jri.2014.12.003. |
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@article{1232720,
author = {Bienertová Vašků, Julie and Zlámal, Filip and Tomandl, Josef and Hodická, Zuzana and Novák, Jan and Šplíchal, Zbyněk and Ventruba, Pavel and Thon, Vojtěch and Vašků, Anna},
article_location = {Clare},
article_number = {JUN 2015},
doi = {http://dx.doi.org/10.1016/j.jri.2014.12.003},
keywords = {BAFF; Breast milk; Cord blood; Lactation; Pre-eclampsia},
language = {eng},
issn = {0165-0378},
journal = {Journal of Reproductive Immunology},
title = {The presence of B-cell activating factor (BAFF) in umbilical cord blood in both healthy and pre-eclamptic pregnancies and in human breast milk.},
volume = {109},
year = {2015}
}
TY - JOUR
ID - 1232720
AU - Bienertová Vašků, Julie - Zlámal, Filip - Tomandl, Josef - Hodická, Zuzana - Novák, Jan - Šplíchal, Zbyněk - Ventruba, Pavel - Thon, Vojtěch - Vašků, Anna
PY - 2015
TI - The presence of B-cell activating factor (BAFF) in umbilical cord blood in both healthy and pre-eclamptic pregnancies and in human breast milk.
JF - Journal of Reproductive Immunology
VL - 109
IS - JUN 2015
SP - 89-93
EP - 89-93
PB - Elsevier Ireland Ltd.
SN - 01650378
KW - BAFF
KW - Breast milk
KW - Cord blood
KW - Lactation
KW - Pre-eclampsia
N2 - B-cell activating factor (BAFF) is an important immune regulator that was recently reported to be secreted by placenta. The aim of the study was to investigate the presence of BAFF in umbilical cord blood, maternal serum, and breast milk in normal and in pre-eclamptic pregnancies. Pairs of maternal serum/umbilical cord blood were obtained from 12 pre-eclamptic and 34 physiological pregnancies. Another cohort of 10 healthy lactating women was established that was followed up for 6 months following delivery to investigate BAFF levels in breast milk. BAFF levels in maternal peripheral blood were significantly higher in physiological pregnancies than in pre-eclamptic pregnancies (p < 0.03). Furthermore, we observed a consistent presence of BAFF in breast milk during the 6-month post-partum period of breastfeeding. In this study, we demonstrate that BAFF levels are significantly lower in maternal peripheral blood in pre-eclamptic pregnancies. We also report the consistent presence of BAFF in breast milk in healthy women. More research into the role of BAFF in pregnancy, and during breastfeeding, is imperative.
ER -
BIENERTOVÁ VAŠKŮ, Julie, Filip ZLÁMAL, Josef TOMANDL, Zuzana HODICKÁ, Jan NOVÁK, Zbyněk ŠPLÍCHAL, Pavel VENTRUBA, Vojtěch THON and Anna VAŠKŮ. The presence of B-cell activating factor (BAFF) in umbilical cord blood in both healthy and pre-eclamptic pregnancies and in human breast milk. \textit{Journal of Reproductive Immunology}. Clare: Elsevier Ireland Ltd., 2015, vol.~109, JUN 2015, p.~89-93. ISSN~0165-0378. Available from: https://dx.doi.org/10.1016/j.jri.2014.12.003.
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