Central Pulse Pressure and Variability in Matrix
Metalloproteinases Genes and Their Inhibitors in Patients With
Ischemic Heart Disease

J 2014

Central Pulse Pressure and Variability in Matrix Metalloproteinases Genes and Their Inhibitors in Patients With Ischemic Heart Disease

VAŠKŮ, Anna, Julie BIENERTOVÁ VAŠKŮ, Jiří PAŘENICA, Monika PÁVKOVÁ GOLDBERGOVÁ, Jan NOVÁK et. al.

Basic information

Original name

Central Pulse Pressure and Variability in Matrix Metalloproteinases Genes and Their Inhibitors in Patients With Ischemic Heart Disease

Authors

VAŠKŮ, Anna (203 Czech Republic, guarantor, belonging to the institution), Julie BIENERTOVÁ VAŠKŮ (203 Czech Republic, belonging to the institution), Jiří PAŘENICA (203 Czech Republic, belonging to the institution), Monika PÁVKOVÁ GOLDBERGOVÁ (203 Czech Republic, belonging to the institution), Jan NOVÁK (203 Czech Republic, belonging to the institution), Monika CHMELÍKOVÁ (203 Czech Republic, belonging to the institution), Dana HONSOVÁ (203 Czech Republic, belonging to the institution), Jolana LIPKOVÁ (203 Czech Republic, belonging to the institution), Petr KALA (203 Czech Republic, belonging to the institution) and Jindřich ŠPINAR (203 Czech Republic, belonging to the institution)

Edition

Physiological Research, Praha, Fyziologický ústav AV ČR, 2014, 0862-8408

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30105 Physiology

Country of publisher

Czech Republic

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 1.293

RIV identification code

RIV/00216224:14110/14:00079956

Organization unit

Faculty of Medicine

UT WoS

000351014100007

Keywords in English

Central pulse pressure; Matrix metalloproteinase; MMP; TIMP; SNP

Abstract

V originále

Matrix metalloproteinases (MMPs) as well as their inhibitors (TIMPs) play a crucial role in controlling extracellular matrix turnover and have recently been associated with atherosclerosis, myocardial and vascular injury. Moreover, the genetic variability of MMP genes has been suggested to play an important role in vascular remodeling and age-related arterial stiffening. This study aims to describe associations of 14 selected polymorphisms in genes for MMPs and TIMPs with selected cardiovascular parameters (including central pulse pressure), clinical conditions and drug treatment profiles in 411 stable ischemic patients with preserved systolic function of the left ventricle. The genotyping of 14 single-nucleotide polymorphisms in 8 genes was carried out either using 5exonuclease (TaqMan®) reagents or by restriction analysis. Numerous associations of the investigated polymorphisms with systolic and diastolic blood pressure, maximum left ventricular end diastolic pressure and ejection fraction were observed. While some of the observed effects were found to be age-dependent, associations with clinical conditions (hypertension, diabetes mellitus, angina pectoris) were only observed in women and associations with four groups of drugs (statins, nitrates, calcium channel blockers, anti-aggregation drugs) were only observed in men. The results of this study indicate that the genetic variability of MMPs and TIMPs is an important factor which influences cardiovascular functions and may have important consequences for individual therapy customization in the future.

Citovat

VAŠKŮ, Anna, Julie BIENERTOVÁ VAŠKŮ, Jiří PAŘENICA, Monika PÁVKOVÁ GOLDBERGOVÁ, Jan NOVÁK, Monika CHMELÍKOVÁ, Dana HONSOVÁ, Jolana LIPKOVÁ, Petr KALA and Jindřich ŠPINAR. Central Pulse Pressure and Variability in Matrix Metalloproteinases Genes and Their Inhibitors in Patients With Ischemic Heart Disease. Physiological Research. Praha: Fyziologický ústav AV ČR, 2014, vol. 63, Suppl. 4, p. "S497"-"S507", 11 pp. ISSN 0862-8408.

@article{1232923,
   author = {Vašků, Anna and Bienertová Vašků, Julie and Pařenica, Jiří and Pávková Goldbergová, Monika and Novák, Jan and Chmelíková, Monika and Honsová, Dana and Lipková, Jolana and Kala, Petr and Špinar, Jindřich},
   article_location = {Praha},
   article_number = {Suppl. 4},
   keywords = {Central pulse pressure; Matrix metalloproteinase; MMP; TIMP; SNP},
   language = {eng},
   issn = {0862-8408},
   journal = {Physiological Research},
   title = {Central Pulse Pressure and Variability in Matrix Metalloproteinases Genes and Their Inhibitors in Patients With Ischemic Heart Disease},
   url = {http://www.biomed.cas.cz/physiolres/pdf/63%20Suppl%204/63_S497.pdf},
   volume = {63},
   year = {2014}
}

TY  - JOUR
ID  - 1232923
AU  - Vašků, Anna - Bienertová Vašků, Julie - Pařenica, Jiří - Pávková Goldbergová, Monika - Novák, Jan - Chmelíková, Monika - Honsová, Dana - Lipková, Jolana - Kala, Petr - Špinar, Jindřich
PY  - 2014
TI  - Central Pulse Pressure and Variability in Matrix Metalloproteinases Genes and Their Inhibitors in Patients With Ischemic Heart Disease
JF  - Physiological Research
VL  - 63
IS  - Suppl. 4
SP  - "S497"-"S507"
EP  - "S497"-"S507"
PB  - Fyziologický ústav AV ČR
SN  - 08628408
KW  - Central pulse pressure
KW  - Matrix metalloproteinase
KW  - MMP
KW  - TIMP
KW  - SNP
UR  - http://www.biomed.cas.cz/physiolres/pdf/63%20Suppl%204/63_S497.pdf
N2  - Matrix metalloproteinases (MMPs) as well as their inhibitors (TIMPs) play a crucial role in controlling extracellular matrix turnover and have recently been associated with atherosclerosis, myocardial and vascular injury. Moreover, the genetic variability of MMP genes has been suggested to play an important role in vascular remodeling and age-related arterial stiffening. This study aims to describe associations of 14 selected polymorphisms in genes for MMPs and TIMPs with selected cardiovascular parameters (including central pulse pressure), clinical conditions and drug treatment profiles in 411 stable ischemic patients with preserved systolic function of the left ventricle. The genotyping of 14 single-nucleotide polymorphisms in 8 genes was carried out either using 5exonuclease (TaqMan®) reagents or by restriction analysis. Numerous associations of the investigated polymorphisms with systolic and diastolic blood pressure, maximum left ventricular end diastolic pressure and ejection fraction were observed. While some of the observed effects were found to be age-dependent, associations with clinical conditions (hypertension, diabetes mellitus, angina pectoris) were only observed in women and associations with four groups of drugs (statins, nitrates, calcium channel blockers, anti-aggregation drugs) were only observed in men. The results of this study indicate that the genetic variability of MMPs and TIMPs is an important factor which influences cardiovascular functions and may have important consequences for individual therapy customization in the future.
ER  -

VAŠKŮ, Anna, Julie BIENERTOVÁ VAŠKŮ, Jiří PAŘENICA, Monika PÁVKOVÁ GOLDBERGOVÁ, Jan NOVÁK, Monika CHMELÍKOVÁ, Dana HONSOVÁ, Jolana LIPKOVÁ, Petr KALA and Jindřich ŠPINAR. Central Pulse Pressure and Variability in Matrix Metalloproteinases Genes and Their Inhibitors in Patients With Ischemic Heart Disease. \textit{Physiological Research}. Praha: Fyziologický ústav AV ČR, 2014, vol.~63, Suppl. 4, p.~''S497''-''S507'', 11 pp. ISSN~0862-8408.

Detailed Information on Publication Record