VAŠKŮ, Anna, Julie BIENERTOVÁ VAŠKŮ, Jiří PAŘENICA, Monika PÁVKOVÁ GOLDBERGOVÁ, Jan NOVÁK, Monika CHMELÍKOVÁ, Dana HONSOVÁ, Jolana LIPKOVÁ, Petr KALA and Jindřich ŠPINAR. Central Pulse Pressure and Variability in Matrix Metalloproteinases Genes and Their Inhibitors in Patients With Ischemic Heart Disease. Physiological Research. Praha: Fyziologický ústav AV ČR, vol. 63, Suppl. 4, p. "S497"-"S507", 11 pp. ISSN 0862-8408. 2014.
Other formats:   BibTeX LaTeX RIS
Basic information
Original name Central Pulse Pressure and Variability in Matrix Metalloproteinases Genes and Their Inhibitors in Patients With Ischemic Heart Disease
Authors VAŠKŮ, Anna (203 Czech Republic, guarantor, belonging to the institution), Julie BIENERTOVÁ VAŠKŮ (203 Czech Republic, belonging to the institution), Jiří PAŘENICA (203 Czech Republic, belonging to the institution), Monika PÁVKOVÁ GOLDBERGOVÁ (203 Czech Republic, belonging to the institution), Jan NOVÁK (203 Czech Republic, belonging to the institution), Monika CHMELÍKOVÁ (203 Czech Republic, belonging to the institution), Dana HONSOVÁ (203 Czech Republic, belonging to the institution), Jolana LIPKOVÁ (203 Czech Republic, belonging to the institution), Petr KALA (203 Czech Republic, belonging to the institution) and Jindřich ŠPINAR (203 Czech Republic, belonging to the institution).
Edition Physiological Research, Praha, Fyziologický ústav AV ČR, 2014, 0862-8408.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30105 Physiology
Country of publisher Czech Republic
Confidentiality degree is not subject to a state or trade secret
WWW URL
Impact factor Impact factor: 1.293
RIV identification code RIV/00216224:14110/14:00079956
Organization unit Faculty of Medicine
UT WoS 000351014100007
Keywords in English Central pulse pressure; Matrix metalloproteinase; MMP; TIMP; SNP
Tags EL OK
Tags International impact, Reviewed
Changed by Changed by: Ing. Mgr. Věra Pospíšilíková, učo 9005. Changed: 24/4/2015 13:10.
Abstract
Matrix metalloproteinases (MMPs) as well as their inhibitors (TIMPs) play a crucial role in controlling extracellular matrix turnover and have recently been associated with atherosclerosis, myocardial and vascular injury. Moreover, the genetic variability of MMP genes has been suggested to play an important role in vascular remodeling and age-related arterial stiffening. This study aims to describe associations of 14 selected polymorphisms in genes for MMPs and TIMPs with selected cardiovascular parameters (including central pulse pressure), clinical conditions and drug treatment profiles in 411 stable ischemic patients with preserved systolic function of the left ventricle. The genotyping of 14 single-nucleotide polymorphisms in 8 genes was carried out either using 5exonuclease (TaqMan®) reagents or by restriction analysis. Numerous associations of the investigated polymorphisms with systolic and diastolic blood pressure, maximum left ventricular end diastolic pressure and ejection fraction were observed. While some of the observed effects were found to be age-dependent, associations with clinical conditions (hypertension, diabetes mellitus, angina pectoris) were only observed in women and associations with four groups of drugs (statins, nitrates, calcium channel blockers, anti-aggregation drugs) were only observed in men. The results of this study indicate that the genetic variability of MMPs and TIMPs is an important factor which influences cardiovascular functions and may have important consequences for individual therapy customization in the future.
PrintDisplayed: 20/4/2024 06:51