Feasibility and diagnostic accuracy of exercise treadmill
nitrogen-13 ammonia PET myocardial perfusion imaging of obese
patients

J 2015

Feasibility and diagnostic accuracy of exercise treadmill nitrogen-13 ammonia PET myocardial perfusion imaging of obese patients

AGGARWAL, Niti R., Adéla DROZDOVÁ, Wells J. ASKEW III, Bradley J. KEMP, Panithaya CHAREONTHAITAWEE et. al.

Basic information

Original name

Feasibility and diagnostic accuracy of exercise treadmill nitrogen-13 ammonia PET myocardial perfusion imaging of obese patients

Authors

AGGARWAL, Niti R. (840 United States of America), Adéla DROZDOVÁ (203 Czech Republic, guarantor, belonging to the institution), Wells J. ASKEW III (840 United States of America), Bradley J. KEMP (840 United States of America) and Panithaya CHAREONTHAITAWEE (840 United States of America)

Edition

Journal of Nuclear Cardiology, New York, Springer, 2015, 1071-3581

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30201 Cardiac and Cardiovascular systems

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 2.929

RIV identification code

RIV/00216224:14110/15:00082685

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1007/s12350-015-0073-z

UT WoS

000365303100018

Keywords in English

Coronary artery disease; exercise stress testing; myocardial perfusion imaging; obesity; positron emission tomography

Abstract

V originále

Background. Treadmill exercise nitrogen-13 (13N)-ammonia positron emission tomography (PET) has logistical challenges and limited literature. We aimed to assess its feasibility, image quality, and diagnostic accuracy in obese and nonobese patients. Methods and Results. Between 2009 and 2012, 10,804 patients were referred for myocardial perfusion imaging, including 300 for treadmill PET, of whom 265 were included in this study. Treadmill testing and PET were performed using standard procedures. Image quality, perfusion, and summed stress score (SSS) were assessed. Invasive coronary angiography was performed within 90 days of PET in 43 patients. Mean ± SD body mass index (BMI) was 35.7 ± 7.7 kg/m2 (range 19.5-63.5 kg/m2). Feasibility of treadmill 13N-ammonia PET was 100%. Exercise duration was less for obese patients than nonobese patients (P < .001). Image quality was rated good for 96.9% of obese and 100% of nonobese patients. For all patients, sensitivity was 86.4% and specificity was 74.4%. Diagnostic accuracy did not change significantly with increasing BMI. SSS remained significant in predicting angiographic coronary artery disease after adjustment for age, sex, and Duke treadmill score. Conclusions. Treadmill 13N-ammonia PET is highly feasible, yields good image quality, and has moderately high diagnostic accuracy in a small subset of obese and nonobese patients who are deemed able to perform treadmill exercise.

Citovat

AGGARWAL, Niti R., Adéla DROZDOVÁ, Wells J. ASKEW III, Bradley J. KEMP and Panithaya CHAREONTHAITAWEE. Feasibility and diagnostic accuracy of exercise treadmill nitrogen-13 ammonia PET myocardial perfusion imaging of obese patients. Journal of Nuclear Cardiology. New York: Springer, 2015, vol. 22, No 6, p. 1273-1280. ISSN 1071-3581. Available from: https://dx.doi.org/10.1007/s12350-015-0073-z.

@article{1297363,
   author = {Aggarwal, Niti R. and Drozdová, Adéla and Askew III, Wells J. and Kemp, Bradley J. and Chareonthaitawee, Panithaya},
   article_location = {New York},
   article_number = {6},
   doi = {http://dx.doi.org/10.1007/s12350-015-0073-z},
   keywords = {Coronary artery disease; exercise stress testing; myocardial perfusion imaging; obesity; positron emission tomography},
   language = {eng},
   issn = {1071-3581},
   journal = {Journal of Nuclear Cardiology},
   title = {Feasibility and diagnostic accuracy of exercise treadmill nitrogen-13 ammonia PET myocardial perfusion imaging of obese patients},
   volume = {22},
   year = {2015}
}

TY  - JOUR
ID  - 1297363
AU  - Aggarwal, Niti R. - Drozdová, Adéla - Askew III, Wells J. - Kemp, Bradley J. - Chareonthaitawee, Panithaya
PY  - 2015
TI  - Feasibility and diagnostic accuracy of exercise treadmill nitrogen-13 ammonia PET myocardial perfusion imaging of obese patients
JF  - Journal of Nuclear Cardiology
VL  - 22
IS  - 6
SP  - 1273-1280
EP  - 1273-1280
PB  - Springer
SN  - 10713581
KW  - Coronary artery disease
KW  - exercise stress testing
KW  - myocardial perfusion imaging
KW  - obesity
KW  - positron emission tomography
N2  - Background. Treadmill exercise nitrogen-13 (13N)-ammonia positron emission tomography (PET) has logistical challenges and limited literature. We aimed to assess its feasibility, image quality, and diagnostic accuracy in obese and nonobese patients. Methods and Results. Between 2009 and 2012, 10,804 patients were referred for myocardial perfusion imaging, including 300 for treadmill PET, of whom 265 were included in this study. Treadmill testing and PET were performed using standard procedures. Image quality, perfusion, and summed stress score (SSS) were assessed. Invasive coronary angiography was performed within 90 days of PET in 43 patients. Mean ± SD body mass index (BMI) was 35.7 ± 7.7 kg/m2 (range 19.5-63.5 kg/m2). Feasibility of treadmill 13N-ammonia PET was 100%. Exercise duration was less for obese patients than nonobese patients (P < .001). Image quality was rated good for 96.9% of obese and 100% of nonobese patients. For all patients, sensitivity was 86.4% and specificity was 74.4%. Diagnostic accuracy did not change significantly with increasing BMI. SSS remained significant in predicting angiographic coronary artery disease after adjustment for age, sex, and Duke treadmill score. Conclusions. Treadmill 13N-ammonia PET is highly feasible, yields good image quality, and has moderately high diagnostic accuracy in a small subset of obese and nonobese patients who are deemed able to perform treadmill exercise.
ER  -

AGGARWAL, Niti R., Adéla DROZDOVÁ, Wells J. ASKEW III, Bradley J. KEMP and Panithaya CHAREONTHAITAWEE. Feasibility and diagnostic accuracy of exercise treadmill nitrogen-13 ammonia PET myocardial perfusion imaging of obese patients. \textit{Journal of Nuclear Cardiology}. New York: Springer, 2015, vol.~22, No~6, p.~1273-1280. ISSN~1071-3581. Available from: https://dx.doi.org/10.1007/s12350-015-0073-z.

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