Analysis of workflow processes with quantitative aspects like timing is of interest in numerous time-critical applications. We suggest a workflow model based on timed-arc Petri nets and study the foundational problems of soundness and strong (time-bounded) soundness. We explore the decidability of these problems and show, among others, that soundness is decidable for monotonic workflow nets while reachability is undecidable. For general timed-arc workflow nets soundness and strong soundness become undecidable, though we can design efficient verification algorithms for the subclass of bounded nets. Finally, we demonstrate the usability of our theory on the case studies of a Brake System Control Unit used in aircraft certification, the MPEG2 encoding algorithm, and a blood transfusion workflow. The implementation of the algorithms is freely available as a part of the model checker TAPAAL.