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@article{1298261,
author = {Kamínek, Milan and Metelková, Iva and Budíková, Miroslava and Koranda, Pavel and Henzlova, Lenka and Havel, Martin and Sovová, Eliška and Kincl, Vladimír},
article_location = {Thessaloniki},
article_number = {1},
keywords = {Cardiac SPET imaging; Multivessel CAD; Postischaemic stunning; Coronary artery calcium scoring},
language = {eng},
issn = {1790-5427},
journal = {Hellenic Journal of Nuclear Medicine},
title = {Diagnosis of high-risk patients with multivessel coronary artery disease by combined cardiac gated SPET imaging and coronary calcium score},
volume = {18},
year = {2015}
}
TY - JOUR
ID - 1298261
AU - Kamínek, Milan - Metelková, Iva - Budíková, Miroslava - Koranda, Pavel - Henzlova, Lenka - Havel, Martin - Sovová, Eliška - Kincl, Vladimír
PY - 2015
TI - Diagnosis of high-risk patients with multivessel coronary artery disease by combined cardiac gated SPET imaging and coronary calcium score
JF - Hellenic Journal of Nuclear Medicine
VL - 18
IS - 1
SP - 31-34
EP - 31-34
PB - HELLENIC SOC NUCLEAR MEDICINE
SN - 17905427
KW - Cardiac SPET imaging
KW - Multivessel CAD
KW - Postischaemic stunning
KW - Coronary artery calcium scoring
N2 - Objective: The added value of coronary artery calcium (CAC) to SPET for identification of multivessel CAD has not been studied yet. The aim of this original study was to investigate CAC as an adjunct to gated single photon emission tomography (GSPET) in the detection of multivessel coronary artery disease (CAD). Subjects and methods: The study group consisted of 164 prospectively recruited patients without known CAD-123 (75%) men and 60 (37%) women, having diabetes type II, renal insufficiency, left ventricular dilatation and other cardiac problems (arrhythmia, necessity of pharmacological stress test, etc.). The mean age of these patients was 61±12 years (range 34-85 years). All these patients underwent GSPET imaging, CAC score measurement, and coronary angiography. The percentage of ischaemic myocardium, stress and rest left ventricular ejection fraction (LVEF), and transient ischaemic dilation (TID) ratio were measured. Results: Patients with multivessel CAD had more frequently reversible defects in multiple territories, severe ischaemia 10% of the left ventricle, stress worsening of the LVEF 5%, TID ratio 1.17, and CAC score >1000. In the detection of multivessel CAD, the sensitivity of combined assessment of perfusion, function, and CAC (i.e., multiple and/or 10% ischaemia, and/or worsening of the LVEF 5%, and/or TID ratio 1.17, and/or CAC score >1000) was significantly higher than the sensitivity of perfusion alone or perfusion and function alone (81% vs. 55% and 65%, respectively, P<0.05). Sensitivity of only CAC was low (41%). Conclusion: Sensitivity of combined assessment of myocardial perfusion, function, and CAC was significantly higher than sensitivity of perfusion alone or perfusion and function alone, suggesting better identification of high-risk patients with CAD.
ER -
KAMÍNEK, Milan, Iva METELKOVÁ, Miroslava BUDÍKOVÁ, Pavel KORANDA, Lenka HENZLOVA, Martin HAVEL, Eliška SOVOVÁ and Vladimír KINCL. Diagnosis of high-risk patients with multivessel coronary artery disease by combined cardiac gated SPET imaging and coronary calcium score. \textit{Hellenic Journal of Nuclear Medicine}. Thessaloniki: HELLENIC SOC NUCLEAR MEDICINE, 2015, vol.~18, No~1, p.~31-34. ISSN~1790-5427.
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