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@proceedings{1298505,
author = {Michalcová, Lenka and Nevídalová, Hana and Glatz, Zdeněk},
booktitle = {CEITEC PhD Retreat},
keywords = {capillary electrophoresis, isothermal titration calorimetry, binding constant},
language = {eng},
isbn = {978-80-210-7825-3},
title = {Comparison of capillary electrophoresis and isothermal titration calorimetry for determination of the binding constant},
year = {2015}
}
TY - CONF
ID - 1298505
AU - Michalcová, Lenka - Nevídalová, Hana - Glatz, Zdeněk
PY - 2015
TI - Comparison of capillary electrophoresis and isothermal titration calorimetry for determination of the binding constant
SN - 9788021078253
KW - capillary electrophoresis, isothermal titration calorimetry, binding constant
N2 - The binding constant is commonly used to describe the strength of binding between ligands (drugs) and protein. The strength of the interaction has a significant effect on the biological activity of the drug, and knowledge of the nature and extent of drug-protein binding can help us to understand the pharmacokinetics and pharmacodynamics of a drug. The binding constant may be determined by various methods. The main objective of the study was to compare the results of capillary electrophoresis and isotermal titration calorimetry.
ER -
MICHALCOVÁ, Lenka, Hana NEVÍDALOVÁ a Zdeněk GLATZ. Comparison of capillary electrophoresis and isothermal titration calorimetry for determination of the binding constant. In \textit{CEITEC PhD Retreat}. 2015. ISBN~978-80-210-7825-3.
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