VYCHYTILOVÁ, Petra, Igor KISS, Soňa KLUSOVÁ, Jan HLAVSA, Vladimír PROCHÁZKA, Zdeněk KALA, Jan MAZANEC, Jitka HAUSNEROVÁ, Leoš KŘEN, Markéta HERMANOVÁ, Jiří LENZ, Petr KARÁSEK, Rostislav VYZULA and Ondřej SLABÝ. MiR-21, miR-34a, miR-198 and miR-217 as diagnostic and prognostic biomarkers for chronic pancreatitis and pancreatic ductal adenocarcinoma. Diagnostic Pathology. LONDON: BIOMED CENTRAL LTD, 2015, vol. 10, April, p. nestránkováno, 5 pp. ISSN 1746-1596. doi:10.1186/s13000-015-0272-6.
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Basic information
Original name MiR-21, miR-34a, miR-198 and miR-217 as diagnostic and prognostic biomarkers for chronic pancreatitis and pancreatic ductal adenocarcinoma.
Authors VYCHYTILOVÁ, Petra (203 Czech Republic, belonging to the institution), Igor KISS (203 Czech Republic), Soňa KLUSOVÁ (703 Slovakia, belonging to the institution), Jan HLAVSA (203 Czech Republic), Vladimír PROCHÁZKA (203 Czech Republic), Zdeněk KALA (203 Czech Republic), Jan MAZANEC (203 Czech Republic), Jitka HAUSNEROVÁ (203 Czech Republic), Leoš KŘEN (203 Czech Republic), Markéta HERMANOVÁ (203 Czech Republic), Jiří LENZ (203 Czech Republic), Petr KARÁSEK (203 Czech Republic), Rostislav VYZULA (203 Czech Republic) and Ondřej SLABÝ (203 Czech Republic, guarantor, belonging to the institution).
Edition Diagnostic Pathology, LONDON, BIOMED CENTRAL LTD, 2015, 1746-1596.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30200 3.2 Clinical medicine
Country of publisher United Kingdom of Great Britain and Northern Ireland
Confidentiality degree is not subject to a state or trade secret
WWW URL
Impact factor Impact factor: 1.895
RIV identification code RIV/00216224:14740/15:00082771
Organization unit Central European Institute of Technology
Doi http://dx.doi.org/10.1186/s13000-015-0272-6
UT WoS 000353329200001
Keywords (in Czech) mikroRNA; duktální adenokarcinom pankreatu; diagnostické biomarkery; prognostické biomarkery; chronická pankreatitida
Keywords in English microRNA; pancreatic ductal adenocarcinoma; diagnostic biomarkers; prognostic biomarkers; chronic pancreatitis
Tags EL OK, OA, podil, rivok
Tags International impact, Reviewed
Changed by Changed by: Olga Křížová, učo 56639. Changed: 3/5/2016 17:02.
Abstract
Background: Pancreatic ductal adenocarcinoma is an aggressive malignancy with late presentation, metastatic potential and very poor prognosis. Therefore, there is an urgent need for novel diagnostic and prognostic biomarkers. MicroRNAs are small non-coding RNAs that post-transcriptionally regulate gene expression. Altered expression of microRNAs has been reported in wide range of malignancies, including pancreatic ductal adenocarcinoma. The aim of this study was to analyze the expression of selected microRNAs in normal pancreas, chronic pancreatitis and pancreatic ductal adenocarcinoma tissues and evaluate their diagnostic and prognostic potential. Findings: Using quantitative real-time PCR, expression levels of 4 microRNAs were examined in 74 tumor tissues, 18 tissues of chronic pancreatitis and 9 adjacent normal tissues and correlated with clinicopathological features of patients. Expression levels of miR-21, miR-34a and miR-198 were significantly higher, whereas levels of miR-217 were significantly lower in pancreatic ductal adenocarcinomas compared to healthy tissues and tissues of chronic pancreatitis. Moreover, increased expression of miR-21 and miR-198 was significantly associated with shorter disease free survival and overall survival. Conclusions: Our data suggest that altered expression of examined microRNAs is related to neoplastic transformation and progression of the disease and these microRNAs could serve as diagnostic and prognostic biomarkers for pancreatic ductal adenocarcinoma.
Links
ED1.1.00/02.0068, research and development projectName: CEITEC - central european institute of technology
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