| VYCHYTILOVÁ, Petra, Igor KISS, Soňa KLUSOVÁ, Jan HLAVSA, Vladimír PROCHÁZKA, Zdeněk KALA, Jan MAZANEC, Jitka HAUSNEROVÁ, Leoš KŘEN, Markéta HERMANOVÁ, Jiří LENZ, Petr KARÁSEK, Rostislav VYZULA a Ondřej SLABÝ. MiR-21, miR-34a, miR-198 and miR-217 as diagnostic and prognostic biomarkers for chronic pancreatitis and pancreatic ductal adenocarcinoma. Diagnostic Pathology. LONDON: BIOMED CENTRAL LTD, 2015, roč. 10, April, s. nestránkováno, 5 s. ISSN 1746-1596. Dostupné z: https://dx.doi.org/10.1186/s13000-015-0272-6. |
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@article{1298551,
author = {Vychytilová, Petra and Kiss, Igor and Klusová, Soňa and Hlavsa, Jan and Procházka, Vladimír and Kala, Zdeněk and Mazanec, Jan and Hausnerová, Jitka and Křen, Leoš and Hermanová, Markéta and Lenz, Jiří and Karásek, Petr and Vyzula, Rostislav and Slabý, Ondřej},
article_location = {LONDON},
article_number = {April},
doi = {http://dx.doi.org/10.1186/s13000-015-0272-6},
keywords = {microRNA; pancreatic ductal adenocarcinoma; diagnostic biomarkers; prognostic biomarkers; chronic pancreatitis},
language = {eng},
issn = {1746-1596},
journal = {Diagnostic Pathology},
title = {MiR-21, miR-34a, miR-198 and miR-217 as diagnostic and prognostic biomarkers for chronic pancreatitis and pancreatic ductal adenocarcinoma.},
url = {http://www.diagnosticpathology.org/content/pdf/s13000-015-0272-6.pdf},
volume = {10},
year = {2015}
}
TY - JOUR
ID - 1298551
AU - Vychytilová, Petra - Kiss, Igor - Klusová, Soňa - Hlavsa, Jan - Procházka, Vladimír - Kala, Zdeněk - Mazanec, Jan - Hausnerová, Jitka - Křen, Leoš - Hermanová, Markéta - Lenz, Jiří - Karásek, Petr - Vyzula, Rostislav - Slabý, Ondřej
PY - 2015
TI - MiR-21, miR-34a, miR-198 and miR-217 as diagnostic and prognostic biomarkers for chronic pancreatitis and pancreatic ductal adenocarcinoma.
JF - Diagnostic Pathology
VL - 10
IS - April
SP - nestránkováno
EP - nestránkováno
PB - BIOMED CENTRAL LTD
SN - 17461596
KW - microRNA
KW - pancreatic ductal adenocarcinoma
KW - diagnostic biomarkers
KW - prognostic biomarkers
KW - chronic pancreatitis
UR - http://www.diagnosticpathology.org/content/pdf/s13000-015-0272-6.pdf
L2 - http://www.diagnosticpathology.org/content/pdf/s13000-015-0272-6.pdf
N2 - Background: Pancreatic ductal adenocarcinoma is an aggressive malignancy with late presentation, metastatic potential and very poor prognosis. Therefore, there is an urgent need for novel diagnostic and prognostic biomarkers. MicroRNAs are small non-coding RNAs that post-transcriptionally regulate gene expression. Altered expression of microRNAs has been reported in wide range of malignancies, including pancreatic ductal adenocarcinoma. The aim of this study was to analyze the expression of selected microRNAs in normal pancreas, chronic pancreatitis and pancreatic ductal adenocarcinoma tissues and evaluate their diagnostic and prognostic potential. Findings: Using quantitative real-time PCR, expression levels of 4 microRNAs were examined in 74 tumor tissues, 18 tissues of chronic pancreatitis and 9 adjacent normal tissues and correlated with clinicopathological features of patients. Expression levels of miR-21, miR-34a and miR-198 were significantly higher, whereas levels of miR-217 were significantly lower in pancreatic ductal adenocarcinomas compared to healthy tissues and tissues of chronic pancreatitis. Moreover, increased expression of miR-21 and miR-198 was significantly associated with shorter disease free survival and overall survival. Conclusions: Our data suggest that altered expression of examined microRNAs is related to neoplastic transformation and progression of the disease and these microRNAs could serve as diagnostic and prognostic biomarkers for pancreatic ductal adenocarcinoma.
ER -
VYCHYTILOVÁ, Petra, Igor KISS, Soňa KLUSOVÁ, Jan HLAVSA, Vladimír PROCHÁZKA, Zdeněk KALA, Jan MAZANEC, Jitka HAUSNEROVÁ, Leoš KŘEN, Markéta HERMANOVÁ, Jiří LENZ, Petr KARÁSEK, Rostislav VYZULA a Ondřej SLABÝ. MiR-21, miR-34a, miR-198 and miR-217 as diagnostic and prognostic biomarkers for chronic pancreatitis and pancreatic ductal adenocarcinoma. \textit{Diagnostic Pathology}. LONDON: BIOMED CENTRAL LTD, 2015, roč.~10, April, s.~nestránkováno, 5 s. ISSN~1746-1596. Dostupné z: https://dx.doi.org/10.1186/s13000-015-0272-6.
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