HÉŽOVÁ, Renata, Alena KOVAŘÍKOVÁ, Josef SROVNAL, Milada ZEMANOVÁ, Tomáš HARUSTIAK, Jiří EHRMANN, Marian HAJDÚCH, Marek SVOBODA, Milana ŠACHLOVÁ a Ondřej SLABÝ. Diagnostic and prognostic potential of miR-21, miR-29c, miR-148 and miR-203 in adenocarcinoma and squamous cell carcinoma of esophagus. Diagnostic Pathology. London: BioMed Central, 2015, roč. 10, April, s. nestránkováno, 6 s. ISSN 1746-1596. doi:10.1186/s13000-015-0280-6.
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Základní údaje
Originální název Diagnostic and prognostic potential of miR-21, miR-29c, miR-148 and miR-203 in adenocarcinoma and squamous cell carcinoma of esophagus
Autoři HÉŽOVÁ, Renata (203 Česká republika, domácí), Alena KOVAŘÍKOVÁ (203 Česká republika, domácí), Josef SROVNAL (203 Česká republika), Milada ZEMANOVÁ (203 Česká republika), Tomáš HARUSTIAK (703 Slovensko), Jiří EHRMANN (203 Česká republika), Marian HAJDÚCH (203 Česká republika), Marek SVOBODA (203 Česká republika, domácí), Milana ŠACHLOVÁ (203 Česká republika) a Ondřej SLABÝ (203 Česká republika, garant, domácí).
Vydání Diagnostic Pathology, London, BioMed Central, 2015, 1746-1596.
Další údaje
Originální jazyk angličtina
Typ výsledku Článek v odborném periodiku
Obor 30200 3.2 Clinical medicine
Stát vydavatele Velká Británie
Utajení není předmětem státního či obchodního tajemství
WWW URL
Impakt faktor Impact factor: 1.895
Kód RIV RIV/00216224:14740/15:00080393
Organizační jednotka Středoevropský technologický institut
Doi http://dx.doi.org/10.1186/s13000-015-0280-6
UT WoS 000353534000004
Klíčová slova anglicky microRNA; diagnostic biomarkers; prognostic biomarkers; adenocarcinoma of esophagus; squamous cell carcinoma of esophagus
Štítky OA, rivok
Příznaky Mezinárodní význam, Recenzováno
Změnil Změnila: Mgr. Eva Špillingová, učo 110713. Změněno: 23. 3. 2016 11:18.
Anotace
Background: Esophageal cancer is the malignant tumor with very poor prognosis and increasing incidence often diagnosed at very late stage, so the prognosis of affected patients is unsatisfactory, despite the development of therapeutic option such as surgery, chemotherapy and radiotherapy. Consequently, there is a great need for biomarkers to allow a tailored multimodality approach with increased efficiency. Altered expression of microRNAs has been reported in wide range of malignancies, including esophageal cancer. The aim of this study was to examine the expression levels of candidate microRNAs in esophageal cancer and evaluate their diagnostic and prognostic potential. Findings: Using quantitative real-time PCR, expression levels of 9 candidate microRNAs were examined in 62 tissue samples, 23 esophageal adenocarcinomas, 22 esophageal squamous cell carcinomas and 17 adjacent esophageal mucosa samples. MicroRNA expression levels were further analyzed in regards to clinico-pathological features of esophageal cancer patients. We observed significantly decreased levels of miR-203 and increased levels of miR-21 in adenocarcinoma tissues when compared to normal mucosa. MiR-29c and miR-148 indicated good ability to distinguish between histological subtypes of esophageal cancer. MiR-203 and miR-148 were linked to disease-free survival and overall survival in esophageal adenocarcinoma patients, and miR-148 also in esophageal squamous cell carcinoma patients. Conclusions: Our data suggest that altered expression of miR-21, miR-29c, miR-148 and miR-203 are related to neoplastic transformation and progression of the disease and these microRNAs could serve as a potential diagnostic and prognostic biomarkers in esophageal cancer.
Návaznosti
ED1.1.00/02.0068, projekt VaVNázev: CEITEC - central european institute of technology
TE02000058, projekt VaVNázev: Centrum kompetence pro molekulární diagnostiku a personalizovanou medicínu (Akronym: MOLDIMED)
Investor: Technologická agentura ČR, Centrum kompetence pro molekulární diagnostiku a personalizovanou medicínu
VytisknoutZobrazeno: 26. 11. 2022 22:57