HÉŽOVÁ, Renata, Alena KOVAŘÍKOVÁ, Josef SROVNAL, Milada ZEMANOVÁ, Tomáš HARUSTIAK, Jiří EHRMANN, Marian HAJDÚCH, Marek SVOBODA, Milana ŠACHLOVÁ and Ondřej SLABÝ. Diagnostic and prognostic potential of miR-21, miR-29c, miR-148 and miR-203 in adenocarcinoma and squamous cell carcinoma of esophagus. Diagnostic Pathology. London: BioMed Central, 2015, vol. 10, April, p. nestránkováno, 6 pp. ISSN 1746-1596. doi:10.1186/s13000-015-0280-6.
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Basic information
Original name Diagnostic and prognostic potential of miR-21, miR-29c, miR-148 and miR-203 in adenocarcinoma and squamous cell carcinoma of esophagus
Authors HÉŽOVÁ, Renata (203 Czech Republic, belonging to the institution), Alena KOVAŘÍKOVÁ (203 Czech Republic, belonging to the institution), Josef SROVNAL (203 Czech Republic), Milada ZEMANOVÁ (203 Czech Republic), Tomáš HARUSTIAK (703 Slovakia), Jiří EHRMANN (203 Czech Republic), Marian HAJDÚCH (203 Czech Republic), Marek SVOBODA (203 Czech Republic, belonging to the institution), Milana ŠACHLOVÁ (203 Czech Republic) and Ondřej SLABÝ (203 Czech Republic, guarantor, belonging to the institution).
Edition Diagnostic Pathology, London, BioMed Central, 2015, 1746-1596.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30200 3.2 Clinical medicine
Country of publisher United Kingdom of Great Britain and Northern Ireland
Confidentiality degree is not subject to a state or trade secret
WWW URL
Impact factor Impact factor: 1.895
RIV identification code RIV/00216224:14740/15:00080393
Organization unit Central European Institute of Technology
Doi http://dx.doi.org/10.1186/s13000-015-0280-6
UT WoS 000353534000004
Keywords in English microRNA; diagnostic biomarkers; prognostic biomarkers; adenocarcinoma of esophagus; squamous cell carcinoma of esophagus
Tags OA, rivok
Tags International impact, Reviewed
Changed by Changed by: Mgr. Eva Špillingová, učo 110713. Changed: 23/3/2016 11:18.
Abstract
Background: Esophageal cancer is the malignant tumor with very poor prognosis and increasing incidence often diagnosed at very late stage, so the prognosis of affected patients is unsatisfactory, despite the development of therapeutic option such as surgery, chemotherapy and radiotherapy. Consequently, there is a great need for biomarkers to allow a tailored multimodality approach with increased efficiency. Altered expression of microRNAs has been reported in wide range of malignancies, including esophageal cancer. The aim of this study was to examine the expression levels of candidate microRNAs in esophageal cancer and evaluate their diagnostic and prognostic potential. Findings: Using quantitative real-time PCR, expression levels of 9 candidate microRNAs were examined in 62 tissue samples, 23 esophageal adenocarcinomas, 22 esophageal squamous cell carcinomas and 17 adjacent esophageal mucosa samples. MicroRNA expression levels were further analyzed in regards to clinico-pathological features of esophageal cancer patients. We observed significantly decreased levels of miR-203 and increased levels of miR-21 in adenocarcinoma tissues when compared to normal mucosa. MiR-29c and miR-148 indicated good ability to distinguish between histological subtypes of esophageal cancer. MiR-203 and miR-148 were linked to disease-free survival and overall survival in esophageal adenocarcinoma patients, and miR-148 also in esophageal squamous cell carcinoma patients. Conclusions: Our data suggest that altered expression of miR-21, miR-29c, miR-148 and miR-203 are related to neoplastic transformation and progression of the disease and these microRNAs could serve as a potential diagnostic and prognostic biomarkers in esophageal cancer.
Links
ED1.1.00/02.0068, research and development projectName: CEITEC - central european institute of technology
TE02000058, research and development projectName: Centrum kompetence pro molekulární diagnostiku a personalizovanou medicínu (Acronym: MOLDIMED)
Investor: Technology Agency of the Czech Republic
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