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@article{1298918,
author = {Slabý, Ondřej and Srovnal, Josef and Radová, Lenka and Gregar, Jan and Juráček, Jaroslav and Lužná, Pavla and Svoboda, Marek and Hajdúch, Marian and Ehramann, Jiří},
article_location = {Oxford},
article_number = {5},
doi = {http://dx.doi.org/10.1093/carcin/bgv023},
keywords = {microRNA; Barrett's esophagus; esophageal carcinoma},
language = {eng},
issn = {0143-3334},
journal = {Carcinogenesis},
title = {Dynamic changes in microRNA expression profiles reflect progression of Barrett's esophagus to esophageal adenocarcinoma},
url = {http://carcin.oxfordjournals.org/content/36/5/521},
volume = {36},
year = {2015}
}
TY - JOUR
ID - 1298918
AU - Slabý, Ondřej - Srovnal, Josef - Radová, Lenka - Gregar, Jan - Juráček, Jaroslav - Lužná, Pavla - Svoboda, Marek - Hajdúch, Marian - Ehramann, Jiří
PY - 2015
TI - Dynamic changes in microRNA expression profiles reflect progression of Barrett's esophagus to esophageal adenocarcinoma
JF - Carcinogenesis
VL - 36
IS - 5
SP - 521-527
EP - 521-527
PB - Oxford University Press
SN - 01433334
KW - microRNA
KW - Barrett's esophagus
KW - esophageal carcinoma
UR - http://carcin.oxfordjournals.org/content/36/5/521
L2 - http://carcin.oxfordjournals.org/content/36/5/521
N2 - Esophageal adenocarcinoma (EAC) is highly aggressive malignancy that frequently develops from Barrett's esophagus (BE), a premalignant pathologic change occurring in the lower end of the esophagus. MicroRNAs (miRNAs) are small, non-coding RNAs that function as posttranscriptional regulators of gene expression and were repeatedly proved to play key roles in pathogenesis of BE as well as EAC. In our study, we used Affymetrix GeneChip miRNA arrays to obtain miRNA expression profiles in total of 119 tissue samples [24 normal esophageal mucosa (EM), 60 BE and 35 EAC]. We identified a number of miRNAs, that showed altered expression progressively in sequence EM, BE and EAC, including for instance miR-21, miR-25, miR-194 and miR-196a with increasing levels (P < 0.0015) and miR-203, miR-205, miR-210 and miR-378 with decreasing levels (P < 0.0001). The subsequent analysis revealed four diagnostic miRNA signatures enabling to distinguish EM and BE [12 miRNAs, area under curve (AUC) = 0.971], EM and EAC (13 miRNAs, AUC = 1.0), BE without and BE with dysplasia (21 miRNAs, AUC = 0.856) and BE without dysplastic changes and BE with dysplasia together with EAC (2 miRNAs, AUC = 0.886). We suggest that miRNA expression profiling expands current knowledge in molecular pathology of Barrett's-based carcinogenesis and enables identification of molecular biomarkers for early detection of BE dysplasia and progression to EAC.
ER -
SLABÝ, Ondřej, Josef SROVNAL, Lenka RADOVÁ, Jan GREGAR, Jaroslav JURÁČEK, Pavla LUŽNÁ, Marek SVOBODA, Marian HAJDÚCH and Jiří EHRAMANN. Dynamic changes in microRNA expression profiles reflect progression of Barrett's esophagus to esophageal adenocarcinoma. \textit{Carcinogenesis}. Oxford: Oxford University Press, 2015, vol.~36, No~5, p.~521-527. ISSN~0143-3334. Available from: https://dx.doi.org/10.1093/carcin/bgv023.
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