Neurochemical and BOLD responses during neuronal activation
measured in the human visual cortex at 7 Tesla

J 2015

Neurochemical and BOLD responses during neuronal activation measured in the human visual cortex at 7 Tesla

BEDNAŘÍK, Petr, Ivan TKAC, Federico GIOVE, Mauro DINUZZO, Dinesh K. DEELCHAND et. al.

Basic information

Original name

Neurochemical and BOLD responses during neuronal activation measured in the human visual cortex at 7 Tesla

Authors

BEDNAŘÍK, Petr (203 Czech Republic, guarantor, belonging to the institution), Ivan TKAC (840 United States of America), Federico GIOVE (380 Italy), Mauro DINUZZO (380 Italy), Dinesh K. DEELCHAND (840 United States of America), Uzay E. EMIR (826 United Kingdom of Great Britain and Northern Ireland), Lynn E. EBERLY (840 United States of America) and Silvia MANGIA (840 United States of America)

Edition

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, NEW YORK, NATURE PUBLISHING GROUP, 2015, 0271-678X

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30000 3. Medical and Health Sciences

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 4.929

RIV identification code

RIV/00216224:14740/15:00082816

Organization unit

Central European Institute of Technology

DOI

http://dx.doi.org/10.1038/jcbfm.2014.233

UT WoS

000352027900010

Keywords in English

Functional Spectroscopy; GABA quantification; Neurochemistry; Visual Stimulation

Abstract

V originále

Several laboratories have consistently reported small concentration changes in lactate, glutamate, aspartate, and glucose in the human cortex during prolonged stimuli. However, whether such changes correlate with blood oxygenation level-dependent functional magnetic resonance imaging (BOLD-fMRI) signals have not been determined. The present study aimed at characterizing the relationship between metabolite concentrations and BOLD-fMRI signals during a block-designed paradigm of visual stimulation. Functional magnetic resonance spectroscopy (fMRS) and fMRI data were acquired from 12 volunteers. A short echo-time semiLASER localization sequence optimized for 7 Tesla was used to achieve full signal-intensity MRS data. The group analysis confirmed that during stimulation lactate and glutamate increased by 0.26 +/- 0.06 mu mol/g (similar to 30%) and 0.28 +/- 0.03 mu mol/g (similar to 3%), respectively, while aspartate and glucose decreased by 0.20 +/- 0.04 mu mol/g (similar to 5%) and 0.19 +/- 0.03 mu mol/g (similar to 16%), respectively. The single-subject analysis revealed that BOLD-fMRI signals were positively correlated with glutamate and lactate concentration changes. The results show a linear relationship between metabolic and BOLD responses in the presence of strong excitatory sensory inputs, and support the notion that increased functional energy demands are sustained by oxidative metabolism. In addition, BOLD signals were inversely correlated with baseline.-aminobutyric acid concentration. Finally, we discussed the critical importance of taking into account linewidth effects on metabolite quantification in fMRS paradigms.

Links

ED1.1.00/02.0068, research and development project

Name: CEITEC - central european institute of technology

Citovat

BEDNAŘÍK, Petr, Ivan TKAC, Federico GIOVE, Mauro DINUZZO, Dinesh K. DEELCHAND, Uzay E. EMIR, Lynn E. EBERLY and Silvia MANGIA. Neurochemical and BOLD responses during neuronal activation measured in the human visual cortex at 7 Tesla. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM. NEW YORK: NATURE PUBLISHING GROUP, 2015, vol. 35, No 4, p. 601-610. ISSN 0271-678X. Available from: https://dx.doi.org/10.1038/jcbfm.2014.233.

@article{1298992,
   author = {Bednařík, Petr and Tkac, Ivan and Giove, Federico and DiNuzzo, Mauro and Deelchand, Dinesh K. and Emir, Uzay E. and Eberly, Lynn E. and Mangia, Silvia},
   article_location = {NEW YORK},
   article_number = {4},
   doi = {http://dx.doi.org/10.1038/jcbfm.2014.233},
   keywords = {Functional Spectroscopy; GABA quantification; Neurochemistry; Visual Stimulation},
   language = {eng},
   issn = {0271-678X},
   journal = {JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM},
   title = {Neurochemical and BOLD responses during neuronal activation measured in the human visual cortex at 7 Tesla},
   url = {http://www.nature.com/jcbfm/journal/v35/n4/full/jcbfm2014233a.html},
   volume = {35},
   year = {2015}
}

TY  - JOUR
ID  - 1298992
AU  - Bednařík, Petr - Tkac, Ivan - Giove, Federico - DiNuzzo, Mauro - Deelchand, Dinesh K. - Emir, Uzay E. - Eberly, Lynn E. - Mangia, Silvia
PY  - 2015
TI  - Neurochemical and BOLD responses during neuronal activation measured in the human visual cortex at 7 Tesla
JF  - JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
VL  - 35
IS  - 4
SP  - 601-610
EP  - 601-610
PB  - NATURE PUBLISHING GROUP
SN  - 0271678X
KW  - Functional Spectroscopy
KW  - GABA quantification
KW  - Neurochemistry
KW  - Visual Stimulation
UR  - http://www.nature.com/jcbfm/journal/v35/n4/full/jcbfm2014233a.html
L2  - http://www.nature.com/jcbfm/journal/v35/n4/full/jcbfm2014233a.html
N2  - Several laboratories have consistently reported small concentration changes in lactate, glutamate, aspartate, and glucose in the human cortex during prolonged stimuli. However, whether such changes correlate with blood oxygenation level-dependent functional magnetic resonance imaging (BOLD-fMRI) signals have not been determined. The present study aimed at characterizing the relationship between metabolite concentrations and BOLD-fMRI signals during a block-designed paradigm of visual stimulation. Functional magnetic resonance spectroscopy (fMRS) and fMRI data were acquired from 12 volunteers. A short echo-time semiLASER localization sequence optimized for 7 Tesla was used to achieve full signal-intensity MRS data. The group analysis confirmed that during stimulation lactate and glutamate increased by 0.26 +/- 0.06 mu mol/g (similar to 30%) and 0.28 +/- 0.03 mu mol/g (similar to 3%), respectively, while aspartate and glucose decreased by 0.20 +/- 0.04 mu mol/g (similar to 5%) and 0.19 +/- 0.03 mu mol/g (similar to 16%), respectively. The single-subject analysis revealed that BOLD-fMRI signals were positively correlated with glutamate and lactate concentration changes. The results show a linear relationship between metabolic and BOLD responses in the presence of strong excitatory sensory inputs, and support the notion that increased functional energy demands are sustained by oxidative metabolism. In addition, BOLD signals were inversely correlated with baseline.-aminobutyric acid concentration. Finally, we discussed the critical importance of taking into account linewidth effects on metabolite quantification in fMRS paradigms.
ER  -

BEDNAŘÍK, Petr, Ivan TKAC, Federico GIOVE, Mauro DINUZZO, Dinesh K. DEELCHAND, Uzay E. EMIR, Lynn E. EBERLY and Silvia MANGIA. Neurochemical and BOLD responses during neuronal activation measured in the human visual cortex at 7 Tesla. \textit{JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM}. NEW YORK: NATURE PUBLISHING GROUP, 2015, vol.~35, No~4, p.~601-610. ISSN~0271-678X. Available from: https://dx.doi.org/10.1038/jcbfm.2014.233.

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