Detailed Information on Publication Record
2015
Can Biomarkers Help to Diagnose Early Heart Failure with Preserved Ejection Fraction?
MELUZÍN, Jaroslav and Josef TOMANDLBasic information
Original name
Can Biomarkers Help to Diagnose Early Heart Failure with Preserved Ejection Fraction?
Authors
MELUZÍN, Jaroslav (203 Czech Republic, guarantor, belonging to the institution) and Josef TOMANDL (203 Czech Republic, belonging to the institution)
Edition
Disease Markers, New York, Hindawi Publishing Corporation, 2015, 0278-0240
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
30201 Cardiac and Cardiovascular systems
Country of publisher
United States of America
Confidentiality degree
není předmětem státního či obchodního tajemství
Impact factor
Impact factor: 2.137
RIV identification code
RIV/00216224:14110/15:00082909
Organization unit
Faculty of Medicine
UT WoS
000349241700001
Keywords in English
Biomarkers; Heart Failure
Tags
Tags
International impact, Reviewed
Změněno: 19/5/2015 16:13, Soňa Böhmová
Abstract
V originále
Early heart failure with preserved ejection fraction (HFpEF) is a frequent disease, but its diagnosis is difficult and relies mostly on the evidence of left ventricular filling pressure (LVFP) elevation during exercise. Several reports have suggested that natriuretic peptides plasma levels reflect exercise-induced increase in LVFP, but they still have significant limitations. In this context, any new laboratory biomarker that can accurately reflect LVFP elevation during exercise is desirable. Recently, cardiotrophin-1, soluble endoglin, ST2, growth differentiation factor 15, galectin-3, and other new laboratory markers associated with LVFP have emerged. However, the current data on the relationship of these biomarkers and diastolic dysfunction are limited to resting conditions. Therefore, their secretion deserves to be tested under the exercise to determine their potential role in making a diagnosis of early HFpEF.