J 2015

Can Biomarkers Help to Diagnose Early Heart Failure with Preserved Ejection Fraction?

MELUZÍN, Jaroslav and Josef TOMANDL

Basic information

Original name

Can Biomarkers Help to Diagnose Early Heart Failure with Preserved Ejection Fraction?

Authors

MELUZÍN, Jaroslav (203 Czech Republic, guarantor, belonging to the institution) and Josef TOMANDL (203 Czech Republic, belonging to the institution)

Edition

Disease Markers, New York, Hindawi Publishing Corporation, 2015, 0278-0240

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30201 Cardiac and Cardiovascular systems

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 2.137

RIV identification code

RIV/00216224:14110/15:00082909

Organization unit

Faculty of Medicine

UT WoS

000349241700001

Keywords in English

Biomarkers; Heart Failure

Tags

Tags

International impact, Reviewed
Změněno: 19/5/2015 16:13, Soňa Böhmová

Abstract

V originále

Early heart failure with preserved ejection fraction (HFpEF) is a frequent disease, but its diagnosis is difficult and relies mostly on the evidence of left ventricular filling pressure (LVFP) elevation during exercise. Several reports have suggested that natriuretic peptides plasma levels reflect exercise-induced increase in LVFP, but they still have significant limitations. In this context, any new laboratory biomarker that can accurately reflect LVFP elevation during exercise is desirable. Recently, cardiotrophin-1, soluble endoglin, ST2, growth differentiation factor 15, galectin-3, and other new laboratory markers associated with LVFP have emerged. However, the current data on the relationship of these biomarkers and diastolic dysfunction are limited to resting conditions. Therefore, their secretion deserves to be tested under the exercise to determine their potential role in making a diagnosis of early HFpEF.