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@article{1299771, author = {Olejníčková, Veronika and Nováková, Marie and Provaznik, Ivo}, article_location = {Heidelberg}, article_number = {7}, doi = {http://dx.doi.org/10.1007/s11517-015-1270-2}, keywords = {Isolated heart; Langendorff · Neely; Monophasic action potential; Electrogram}, language = {eng}, issn = {0140-0118}, journal = {Medical & Biological Engineering & Computing}, title = {Isolated heart models: cardiovascular system studies and technological advances}, volume = {53}, year = {2015} }
TY - JOUR ID - 1299771 AU - Olejníčková, Veronika - Nováková, Marie - Provaznik, Ivo PY - 2015 TI - Isolated heart models: cardiovascular system studies and technological advances JF - Medical & Biological Engineering & Computing VL - 53 IS - 7 SP - 669-678 EP - 669-678 PB - Springer Heidelberg SN - 01400118 KW - Isolated heart KW - Langendorff · Neely KW - Monophasic action potential KW - Electrogram N2 - Isolated heart model is a relevant tool for cardiovascular system studies. It represents a highly reproducible model for studying broad spectrum of biochemical, physiological, morphological, and pharmaceutical parameters, including analysis of intrinsic heart mechanics, metabolism, and coronary vascular response. Results obtained in this model are under no influence of other organ systems, plasma concentration of hormones or ions and influence of autonomic nervous system. The review describes various isolated heart models, the modes of heart perfusion, and advantages and limitations of various experimental setups. It reports the improvements of perfusion setup according to Langendorff introduced by the authors. ER -
OLEJNÍČKOVÁ, Veronika, Marie NOVÁKOVÁ and Ivo PROVAZNIK. Isolated heart models: cardiovascular system studies and technological advances. \textit{Medical \&{} Biological Engineering \&{} Computing}. Heidelberg: Springer Heidelberg, 2015, vol.~53, No~7, p.~669-678. ISSN~0140-0118. Available from: https://dx.doi.org/10.1007/s11517-015-1270-2.
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