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@article{1299771,
author = {Olejníčková, Veronika and Nováková, Marie and Provaznik, Ivo},
article_location = {Heidelberg},
article_number = {7},
doi = {http://dx.doi.org/10.1007/s11517-015-1270-2},
keywords = {Isolated heart; Langendorff · Neely; Monophasic action potential; Electrogram},
language = {eng},
issn = {0140-0118},
journal = {Medical & Biological Engineering & Computing},
title = {Isolated heart models: cardiovascular system studies and technological advances},
volume = {53},
year = {2015}
}
TY - JOUR
ID - 1299771
AU - Olejníčková, Veronika - Nováková, Marie - Provaznik, Ivo
PY - 2015
TI - Isolated heart models: cardiovascular system studies and technological advances
JF - Medical & Biological Engineering & Computing
VL - 53
IS - 7
SP - 669-678
EP - 669-678
PB - Springer Heidelberg
SN - 01400118
KW - Isolated heart
KW - Langendorff · Neely
KW - Monophasic action potential
KW - Electrogram
N2 - Isolated heart model is a relevant tool for cardiovascular system studies. It represents a highly reproducible model for studying broad spectrum of biochemical, physiological, morphological, and pharmaceutical parameters, including analysis of intrinsic heart mechanics, metabolism, and coronary vascular response. Results obtained in this model are under no influence of other organ systems, plasma concentration of hormones or ions and influence of autonomic nervous system. The review describes various isolated heart models, the modes of heart perfusion, and advantages and limitations of various experimental setups. It reports the improvements of perfusion setup according to Langendorff introduced by the authors.
ER -
OLEJNÍČKOVÁ, Veronika, Marie NOVÁKOVÁ and Ivo PROVAZNIK. Isolated heart models: cardiovascular system studies and technological advances. \textit{Medical \&{} Biological Engineering \&{} Computing}. Heidelberg: Springer Heidelberg, 2015, vol.~53, No~7, p.~669-678. ISSN~0140-0118. Available from: https://dx.doi.org/10.1007/s11517-015-1270-2.
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