| SUN, Xiaolong, Karel LACINA, Elena C. RAMSAMY, Stephen E. FLOWER, John S. FOSSEY, Xuhong QIAN, Eric V. ANSLYN, Steven D. BULL and Tony D. JAMES. Reaction-based Indicator displacement Assay (RIA) for the selective colorimetric and fluorometric detection of peroxynitrite. CHEMICAL SCIENCE. CAMBRIDGE: ROYAL SOC CHEMISTRY, 2015, vol. 6, No 5, p. 2963-2967. ISSN 2041-6520. Available from: https://dx.doi.org/10.1039/c4sc03983a. |
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@article{1299842,
author = {Sun, Xiaolong and Lacina, Karel and Ramsamy, Elena C. and Flower, Stephen E. and Fossey, John S. and Qian, Xuhong and Anslyn, Eric V. and Bull, Steven D. and James, Tony D.},
article_location = {CAMBRIDGE},
article_number = {5},
doi = {http://dx.doi.org/10.1039/c4sc03983a},
keywords = {APPENDED BIPYRIDINIUM SALTS; BORONIC ACID; HYDROGEN-PEROXIDE; NITRIC-OXIDE; FLUORESCENT-PROBES; SENSING SYSTEM; GLUCOSE; CHEMOSENSOR; REPORTER; VIOLOGEN},
language = {eng},
issn = {2041-6520},
journal = {CHEMICAL SCIENCE},
title = {Reaction-based Indicator displacement Assay (RIA) for the selective colorimetric and fluorometric detection of peroxynitrite},
url = {http://pubs.rsc.org/en/content/articlelanding/2015/sc/c4sc03983a#!divAbstract},
volume = {6},
year = {2015}
}
TY - JOUR
ID - 1299842
AU - Sun, Xiaolong - Lacina, Karel - Ramsamy, Elena C. - Flower, Stephen E. - Fossey, John S. - Qian, Xuhong - Anslyn, Eric V. - Bull, Steven D. - James, Tony D.
PY - 2015
TI - Reaction-based Indicator displacement Assay (RIA) for the selective colorimetric and fluorometric detection of peroxynitrite
JF - CHEMICAL SCIENCE
VL - 6
IS - 5
SP - 2963-2967
EP - 2963-2967
PB - ROYAL SOC CHEMISTRY
SN - 20416520
KW - APPENDED BIPYRIDINIUM SALTS
KW - BORONIC ACID
KW - HYDROGEN-PEROXIDE
KW - NITRIC-OXIDE
KW - FLUORESCENT-PROBES
KW - SENSING SYSTEM
KW - GLUCOSE
KW - CHEMOSENSOR
KW - REPORTER
KW - VIOLOGEN
UR - http://pubs.rsc.org/en/content/articlelanding/2015/sc/c4sc03983a#!divAbstract
L2 - http://pubs.rsc.org/en/content/articlelanding/2015/sc/c4sc03983a#!divAbstract
N2 - Using the self-assembly of aromatic boronic acids with Alizarin Red S (ARS), we developed a new chemosensor for the selective detection of peroxynitrite. Phenylboronic acid (PBA), benzoboroxole (BBA) and 2-(N,N-dimethylaminomethyl)phenylboronic acid (NBA) were employed to bind with ARS to form the complex probes. In particular, the ARS–NBA system with a high binding affinity can preferably react with peroxynitrite over hydrogen peroxide and other ROS/RNS due to the protection of the boron via the solvent-insertion B–N interaction. Our simple system produces a visible colorimetric change and on–off fluorescence response towards peroxynitrite. By coupling a chemical reaction that leads to an indicator displacement, we have developed a new sensing strategy, referred to herein as RIA (Reactionbased Indicator displacement Assay).
ER -
SUN, Xiaolong, Karel LACINA, Elena C. RAMSAMY, Stephen E. FLOWER, John S. FOSSEY, Xuhong QIAN, Eric V. ANSLYN, Steven D. BULL and Tony D. JAMES. Reaction-based Indicator displacement Assay (RIA) for the selective colorimetric and fluorometric detection of peroxynitrite. \textit{CHEMICAL SCIENCE}. CAMBRIDGE: ROYAL SOC CHEMISTRY, 2015, vol.~6, No~5, p.~2963-2967. ISSN~2041-6520. Available from: https://dx.doi.org/10.1039/c4sc03983a.
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