GELBÍČOVÁ, Tereza, Ivana KOLÁČKOVÁ, Roman PANTŮČEK and Renata KARPÍŠKOVÁ. A novel mutation leading to a premature stop codon in inlA of Listeria monocytogenes isolated from neonatal listeriosis. New Microbiologica. Bologna, Italy: Italian Society for Medical Virology (SIVIM), 2015, vol. 38, No 2, p. 293-296. ISSN 1121-7138.
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Basic information
Original name A novel mutation leading to a premature stop codon in inlA of Listeria monocytogenes isolated from neonatal listeriosis
Authors GELBÍČOVÁ, Tereza (203 Czech Republic, guarantor, belonging to the institution), Ivana KOLÁČKOVÁ (203 Czech Republic), Roman PANTŮČEK (203 Czech Republic, belonging to the institution) and Renata KARPÍŠKOVÁ (203 Czech Republic).
Edition New Microbiologica, Bologna, Italy, Italian Society for Medical Virology (SIVIM), 2015, 1121-7138.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 10600 1.6 Biological sciences
Country of publisher Italy
Confidentiality degree is not subject to a state or trade secret
WWW URL
Impact factor Impact factor: 1.629
RIV identification code RIV/00216224:14310/15:00083011
Organization unit Faculty of Science
UT WoS 000357755400018
Keywords in English truncated internalin A; sequencing; newborn; trans-placental barrier; listeria
Tags AKR, rivok
Tags Reviewed
Changed by Changed by: Mgr. Tereza Miškechová, učo 341652. Changed: 27/10/2022 13:14.
Abstract
The study objective was to investigate whether the strain of L. monocytogenes serotype 1/2c isolated from neonatal listeriosis carries a premature stop codon (PMSC) mutation in the inlA gene. The strain was characterized by serotyping, macrorestriction analysis after digestion with the restriction enzyme AscI, and sequencing of the inlA gene. The tested strain of serotype 1/2c and pulsotype 1 possesses a new type of point mutation leading to a PMSC in the inlA gene and production of truncated internalin A. The case of early onset form of neonatal listeriosis caused by serotype 1/2c with a PMSC mutation in the inlA gene confirmed the transplacental transmission potential of this strain.
Links
EE2.3.20.0183, research and development projectName: Centrum experimentální biomedicíny
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