Detailed Information on Publication Record
2015
Distinct Pattern of Gray Matter Atrophy in Mild Alzheimer’s Disease Impacts on Cognitive Outcomes of Noninvasive Brain Stimulation
ANDERKOVÁ, Ľubomíra, Ilona ELIÁŠOVÁ, Radek MAREČEK, Eva JANOUŠOVÁ, Irena REKTOROVÁ et. al.Basic information
Original name
Distinct Pattern of Gray Matter Atrophy in Mild Alzheimer’s Disease Impacts on Cognitive Outcomes of Noninvasive Brain Stimulation
Authors
ANDERKOVÁ, Ľubomíra (703 Slovakia, belonging to the institution), Ilona ELIÁŠOVÁ (203 Czech Republic, belonging to the institution), Radek MAREČEK (203 Czech Republic, belonging to the institution), Eva JANOUŠOVÁ (203 Czech Republic, belonging to the institution) and Irena REKTOROVÁ (203 Czech Republic, guarantor, belonging to the institution)
Edition
JOURNAL OF ALZHEIMERS DISEASE, AMSTERDAM, IOS PRESS, 2015, 1387-2877
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
30000 3. Medical and Health Sciences
Country of publisher
Netherlands
Confidentiality degree
není předmětem státního či obchodního tajemství
References:
Impact factor
Impact factor: 3.920
RIV identification code
RIV/00216224:14740/15:00083300
Organization unit
Central European Institute of Technology
UT WoS
000360931700023
Keywords in English
noninvasive brain stimulation; Alzheimer's disease; cognitive functions; brain atrophy; source-based morphometry
Tags
International impact, Reviewed
Změněno: 13/3/2018 13:29, Mgr. et Mgr. Ľubomíra Nováková, Ph.D.
Abstract
V originále
Background: Repetitive transcranial magnetic stimulation (rTMS) is a promising tool to study and modulate brain plasticity. Objective: Our aim was to investigate the effects of rTMS on cognitive functions in patients with mild cognitive impairment and Alzheimer’s disease (MCI/AD) and assess the effect of gray matter (GM) atrophy on stimulation outcomes. Methods: Twenty MCI/AD patients participated in the proof-of-concept controlled study. Each patient received three sessions of 10 Hz rTMS of the right inferior frontal gyrus (IFG), the right superior temporal gyrus (STG), and the vertex (VTX, a control stimulation site) in a randomized order. Cognitive functions were tested prior to and immediately after each session. The GM volumetric data of patients were: 1)compared to healthy controls (HC) using source-based morphometry; 2) correlated with rTMS-induced cognitive improvement. Results: The effect of the stimulated site on the difference in cognitive scores was statistically significant for the Word part of the Stroop test (ST-W, p = 0.012, linear mixed models). As compared to the VTX stimulation, patients significantly improved after both IFG and STG stimulation in this cognitive measure. MCI/AD patients had significant GM atrophy in characteristic brain regions as compared to HC (p = 0.029, Bonferroni corrected). The amount of atrophy correlated with the change in ST-W scores after rTMS of the STG. Conclusion: rTMS enhanced cognitive functions in MCI/AD patients. We demonstrated for the first time that distinct pattern of GM atrophy in MCI/AD diminishes the cognitive effects induced by rTMS of the temporal neocortex.
Links
| ED1.1.00/02.0068, research and development project |
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