Distinct Pattern of Gray Matter Atrophy in Mild Alzheimer’s Disease Impacts on Cognitive Outcomes of Noninvasive Brain Stimulation

ANDERKOVÁ, Ľubomíra, Ilona ELIÁŠOVÁ, Radek MAREČEK, Eva JANOUŠOVÁ and Irena REKTOROVÁ. Distinct Pattern of Gray Matter Atrophy in Mild Alzheimer’s Disease Impacts on Cognitive Outcomes of Noninvasive Brain Stimulation. JOURNAL OF ALZHEIMERS DISEASE. AMSTERDAM: IOS PRESS, 2015, vol. 48, No 1, p. 251-260. ISSN 1387-2877. Available from: https://dx.doi.org/10.3233/JAD-150067.

Basic information

• Original name: Distinct Pattern of Gray Matter Atrophy in Mild Alzheimer’s Disease Impacts on Cognitive Outcomes of Noninvasive Brain Stimulation
• Authors: ANDERKOVÁ, Ľubomíra (703 Slovakia, belonging to the institution), Ilona ELIÁŠOVÁ (203 Czech Republic, belonging to the institution), Radek MAREČEK (203 Czech Republic, belonging to the institution), Eva JANOUŠOVÁ (203 Czech Republic, belonging to the institution) and Irena REKTOROVÁ (203 Czech Republic, guarantor, belonging to the institution).
• Edition: JOURNAL OF ALZHEIMERS DISEASE, AMSTERDAM, IOS PRESS, 2015, 1387-2877.

Other information

• Original language: English
• Type of outcome: Article in a journal
• Field of Study: 30000 3. Medical and Health Sciences
• Country of publisher: Netherlands
• Confidentiality degree: is not subject to a state or trade secret
• WWW: URL
• Impact factor: Impact factor: 3.920
• RIV identification code: RIV/00216224:14740/15:00083300
• Organization unit: Central European Institute of Technology
• Doi: http://dx.doi.org/10.3233/JAD-150067
• UT WoS: 000360931700023
• Keywords in English: noninvasive brain stimulation; Alzheimer's disease; cognitive functions; brain atrophy; source-based morphometry
• Tags: EL OK, podil, rivok
• Tags: International impact, Reviewed

Abstract

Background: Repetitive transcranial magnetic stimulation (rTMS) is a promising tool to study and modulate brain plasticity. Objective: Our aim was to investigate the effects of rTMS on cognitive functions in patients with mild cognitive impairment and Alzheimer’s disease (MCI/AD) and assess the effect of gray matter (GM) atrophy on stimulation outcomes. Methods: Twenty MCI/AD patients participated in the proof-of-concept controlled study. Each patient received three sessions of 10 Hz rTMS of the right inferior frontal gyrus (IFG), the right superior temporal gyrus (STG), and the vertex (VTX, a control stimulation site) in a randomized order. Cognitive functions were tested prior to and immediately after each session. The GM volumetric data of patients were: 1)compared to healthy controls (HC) using source-based morphometry; 2) correlated with rTMS-induced cognitive improvement. Results: The effect of the stimulated site on the difference in cognitive scores was statistically significant for the Word part of the Stroop test (ST-W, p = 0.012, linear mixed models). As compared to the VTX stimulation, patients significantly improved after both IFG and STG stimulation in this cognitive measure. MCI/AD patients had significant GM atrophy in characteristic brain regions as compared to HC (p = 0.029, Bonferroni corrected). The amount of atrophy correlated with the change in ST-W scores after rTMS of the STG. Conclusion: rTMS enhanced cognitive functions in MCI/AD patients. We demonstrated for the first time that distinct pattern of GM atrophy in MCI/AD diminishes the cognitive effects induced by rTMS of the temporal neocortex.

Links

• ED1.1.00/02.0068, research and development project: Name: CEITEC - central european institute of technology