| WAN, Ilynn, Ondřej POKORA, Tzaiwen CHIU, Petr LÁNSKÝ a Paul Waifung POON. Altered intensity coding in the salicylate-overdose animal model of tinnitus. BioSystems. ELSEVIER SCI LTD, 2015, roč. 136, october, s. 113-119. ISSN 0303-2647. Dostupné z: https://dx.doi.org/10.1016/j.biosystems.2015.06.010. |
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@article{1305279,
author = {Wan, Ilynn and Pokora, Ondřej and Chiu, Tzaiwen and Lánský, Petr and Poon, Paul Waifung},
article_number = {october},
doi = {http://dx.doi.org/10.1016/j.biosystems.2015.06.010},
keywords = {Auditory evoked ponetial; Electrocorticogram; Fisher information; Salicylate-overdose; Tinnitus; Rat},
language = {eng},
issn = {0303-2647},
journal = {BioSystems},
title = {Altered intensity coding in the salicylate-overdose animal model of tinnitus},
volume = {136},
year = {2015}
}
TY - JOUR
ID - 1305279
AU - Wan, Ilynn - Pokora, Ondřej - Chiu, Tzaiwen - Lánský, Petr - Poon, Paul Waifung
PY - 2015
TI - Altered intensity coding in the salicylate-overdose animal model of tinnitus
JF - BioSystems
VL - 136
IS - october
SP - 113-119
EP - 113-119
PB - ELSEVIER SCI LTD
SN - 03032647
KW - Auditory evoked ponetial
KW - Electrocorticogram
KW - Fisher information
KW - Salicylate-overdose
KW - Tinnitus
KW - Rat
N2 - Tinnitus is one of the leading disorders of hearing with no effective cure as its pathophysiological mechanisms remain unclear. While the sensitivity to sound is well-known to be affected, exactly how intensity coding per se is altered remains unclear. To address this issue, we used a salicylate-overdose animal model of tinnitus to measure auditory cortical evoked potentials at various stimulus levels, and analyzed on single-trial basis the response strength and its variance for the computation of the lower bound of Fisher information. Based on Fisher information profiles, we compared the precision or efficiency of intensity coding before and after salicylate-treatment. We found that after salicylate treatment, intensity coding was unexpectedly improved, rather than impaired. Also, the improvement varied in a sound-dependent way. The observed changes are likely due to some central compensatory mechanisms that are activated during tinnitus to bring out the full capacity of intensity coding which is expressed only in part under normal conditions.
ER -
WAN, Ilynn, Ondřej POKORA, Tzaiwen CHIU, Petr LÁNSKÝ a Paul Waifung POON. Altered intensity coding in the salicylate-overdose animal model of tinnitus. \textit{BioSystems}. ELSEVIER SCI LTD, 2015, roč.~136, october, s.~113-119. ISSN~0303-2647. Dostupné z: https://dx.doi.org/10.1016/j.biosystems.2015.06.010.
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