WAN, Ilynn, Ondřej POKORA, Tzaiwen CHIU, Petr LÁNSKÝ and Paul Waifung POON. Altered intensity coding in the salicylate-overdose animal model of tinnitus. BioSystems. ELSEVIER SCI LTD, 2015, vol. 136, october, p. 113-119. ISSN 0303-2647. Available from: https://dx.doi.org/10.1016/j.biosystems.2015.06.010.
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Basic information
Original name Altered intensity coding in the salicylate-overdose animal model of tinnitus
Authors WAN, Ilynn (156 China), Ondřej POKORA (203 Czech Republic, guarantor, belonging to the institution), Tzaiwen CHIU (156 China), Petr LÁNSKÝ (203 Czech Republic) and Paul Waifung POON (156 China).
Edition BioSystems, ELSEVIER SCI LTD, 2015, 0303-2647.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 10101 Pure mathematics
Country of publisher United Kingdom of Great Britain and Northern Ireland
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 1.495
RIV identification code RIV/00216224:14310/15:00083312
Organization unit Faculty of Science
Doi http://dx.doi.org/10.1016/j.biosystems.2015.06.010
UT WoS 000366535200014
Keywords in English Auditory evoked ponetial; Electrocorticogram; Fisher information; Salicylate-overdose; Tinnitus; Rat
Tags AKR, rivok
Tags International impact, Reviewed
Changed by Changed by: Ing. Andrea Mikešková, učo 137293. Changed: 24/3/2016 15:15.
Abstract
Tinnitus is one of the leading disorders of hearing with no effective cure as its pathophysiological mechanisms remain unclear. While the sensitivity to sound is well-known to be affected, exactly how intensity coding per se is altered remains unclear. To address this issue, we used a salicylate-overdose animal model of tinnitus to measure auditory cortical evoked potentials at various stimulus levels, and analyzed on single-trial basis the response strength and its variance for the computation of the lower bound of Fisher information. Based on Fisher information profiles, we compared the precision or efficiency of intensity coding before and after salicylate-treatment. We found that after salicylate treatment, intensity coding was unexpectedly improved, rather than impaired. Also, the improvement varied in a sound-dependent way. The observed changes are likely due to some central compensatory mechanisms that are activated during tinnitus to bring out the full capacity of intensity coding which is expressed only in part under normal conditions.
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