Detailed Information on Publication Record
2015
Altered intensity coding in the salicylate-overdose animal model of tinnitus
WAN, Ilynn, Ondřej POKORA, Tzaiwen CHIU, Petr LÁNSKÝ, Paul Waifung POON et. al.Basic information
Original name
Altered intensity coding in the salicylate-overdose animal model of tinnitus
Authors
WAN, Ilynn (156 China), Ondřej POKORA (203 Czech Republic, guarantor, belonging to the institution), Tzaiwen CHIU (156 China), Petr LÁNSKÝ (203 Czech Republic) and Paul Waifung POON (156 China)
Edition
BioSystems, ELSEVIER SCI LTD, 2015, 0303-2647
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
10101 Pure mathematics
Country of publisher
United Kingdom of Great Britain and Northern Ireland
Confidentiality degree
není předmětem státního či obchodního tajemství
Impact factor
Impact factor: 1.495
RIV identification code
RIV/00216224:14310/15:00083312
Organization unit
Faculty of Science
UT WoS
000366535200014
Keywords in English
Auditory evoked ponetial; Electrocorticogram; Fisher information; Salicylate-overdose; Tinnitus; Rat
Tags
International impact, Reviewed
Změněno: 24/3/2016 15:15, Ing. Andrea Mikešková
Abstract
V originále
Tinnitus is one of the leading disorders of hearing with no effective cure as its pathophysiological mechanisms remain unclear. While the sensitivity to sound is well-known to be affected, exactly how intensity coding per se is altered remains unclear. To address this issue, we used a salicylate-overdose animal model of tinnitus to measure auditory cortical evoked potentials at various stimulus levels, and analyzed on single-trial basis the response strength and its variance for the computation of the lower bound of Fisher information. Based on Fisher information profiles, we compared the precision or efficiency of intensity coding before and after salicylate-treatment. We found that after salicylate treatment, intensity coding was unexpectedly improved, rather than impaired. Also, the improvement varied in a sound-dependent way. The observed changes are likely due to some central compensatory mechanisms that are activated during tinnitus to bring out the full capacity of intensity coding which is expressed only in part under normal conditions.