WAN, Ilynn, Ondřej POKORA, Tzaiwen CHIU, Petr LÁNSKÝ and Paul Waifung POON. Altered intensity coding in the salicylate-overdose animal model of tinnitus. BioSystems. ELSEVIER SCI LTD, 2015, vol. 136, october, p. 113-119. ISSN 0303-2647. Available from: https://dx.doi.org/10.1016/j.biosystems.2015.06.010. |
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@article{1305279, author = {Wan, Ilynn and Pokora, Ondřej and Chiu, Tzaiwen and Lánský, Petr and Poon, Paul Waifung}, article_number = {october}, doi = {http://dx.doi.org/10.1016/j.biosystems.2015.06.010}, keywords = {Auditory evoked ponetial; Electrocorticogram; Fisher information; Salicylate-overdose; Tinnitus; Rat}, language = {eng}, issn = {0303-2647}, journal = {BioSystems}, title = {Altered intensity coding in the salicylate-overdose animal model of tinnitus}, volume = {136}, year = {2015} }
TY - JOUR ID - 1305279 AU - Wan, Ilynn - Pokora, Ondřej - Chiu, Tzaiwen - Lánský, Petr - Poon, Paul Waifung PY - 2015 TI - Altered intensity coding in the salicylate-overdose animal model of tinnitus JF - BioSystems VL - 136 IS - october SP - 113-119 EP - 113-119 PB - ELSEVIER SCI LTD SN - 03032647 KW - Auditory evoked ponetial KW - Electrocorticogram KW - Fisher information KW - Salicylate-overdose KW - Tinnitus KW - Rat N2 - Tinnitus is one of the leading disorders of hearing with no effective cure as its pathophysiological mechanisms remain unclear. While the sensitivity to sound is well-known to be affected, exactly how intensity coding per se is altered remains unclear. To address this issue, we used a salicylate-overdose animal model of tinnitus to measure auditory cortical evoked potentials at various stimulus levels, and analyzed on single-trial basis the response strength and its variance for the computation of the lower bound of Fisher information. Based on Fisher information profiles, we compared the precision or efficiency of intensity coding before and after salicylate-treatment. We found that after salicylate treatment, intensity coding was unexpectedly improved, rather than impaired. Also, the improvement varied in a sound-dependent way. The observed changes are likely due to some central compensatory mechanisms that are activated during tinnitus to bring out the full capacity of intensity coding which is expressed only in part under normal conditions. ER -
WAN, Ilynn, Ondřej POKORA, Tzaiwen CHIU, Petr LÁNSKÝ and Paul Waifung POON. Altered intensity coding in the salicylate-overdose animal model of tinnitus. \textit{BioSystems}. ELSEVIER SCI LTD, 2015, vol.~136, october, p.~113-119. ISSN~0303-2647. Available from: https://dx.doi.org/10.1016/j.biosystems.2015.06.010.
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