| KRATOCHVÍLOVÁ, Kateřina, Peter HORAK, Milan EŠNER, Karel SOUČEK, Dietmar PILS, Mariam ANEES, Erwin TOMASICH, František DRÁFI, Veronika JURTÍKOVÁ, Aleš HAMPL, Michael KRAINER and Petr VAŇHARA. Tumor suppressor candidate 3 (TUSC3) prevents the epithelialto- mesenchymal transition and inhibits tumor growth by modulating the endoplasmic reticulum stress response in ovarian cancer cells. International Journal of Cancer. Hoboken: Wiley-Blackwell, 2015, vol. 137, No 6, p. 1330-1340. ISSN 0020-7136. Available from: https://dx.doi.org/10.1002/ijc.29502. |
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@article{1305771,
author = {Kratochvílová, Kateřina and Horak, Peter and Ešner, Milan and Souček, Karel and Pils, Dietmar and Anees, Mariam and Tomasich, Erwin and Dráfi, František and Jurtíková, Veronika and Hampl, Aleš and Krainer, Michael and Vaňhara, Petr},
article_location = {Hoboken},
article_number = {6},
doi = {http://dx.doi.org/10.1002/ijc.29502},
keywords = {TUSC3; N33; endoplasmic reticulum stress; epithelial-to-mesenchymal transition; ovarian cancer; tumor suppressor},
language = {eng},
issn = {0020-7136},
journal = {International Journal of Cancer},
title = {Tumor suppressor candidate 3 (TUSC3) prevents the epithelialto- mesenchymal transition and inhibits tumor growth by modulating the endoplasmic reticulum stress response in ovarian cancer cells},
volume = {137},
year = {2015}
}
TY - JOUR
ID - 1305771
AU - Kratochvílová, Kateřina - Horak, Peter - Ešner, Milan - Souček, Karel - Pils, Dietmar - Anees, Mariam - Tomasich, Erwin - Dráfi, František - Jurtíková, Veronika - Hampl, Aleš - Krainer, Michael - Vaňhara, Petr
PY - 2015
TI - Tumor suppressor candidate 3 (TUSC3) prevents the epithelialto- mesenchymal transition and inhibits tumor growth by modulating the endoplasmic reticulum stress response in ovarian cancer cells
JF - International Journal of Cancer
VL - 137
IS - 6
SP - 1330-1340
EP - 1330-1340
PB - Wiley-Blackwell
SN - 00207136
KW - TUSC3
KW - N33
KW - endoplasmic reticulum stress
KW - epithelial-to-mesenchymal transition
KW - ovarian cancer
KW - tumor suppressor
N2 - Ovarian cancer is one of the most common malignancies in women and contributes greatly to cancer-related deaths. Tumor suppressor candidate 3 (TUSC3) is a putative tumor suppressor gene located at chromosomal region 8p22, which is often lost in epithelial cancers. Epigenetic silencing of TUSC3 has been associated with poor prognosis, and hypermethylation of its promoter provides an independent biomarker of overall and disease-free survival in ovarian cancer patients. TUSC3 is localized to the endoplasmic reticulum in an oligosaccharyl tranferase complex responsible for the N-glycosylation of proteins. However, the precise molecular role of TUSC3 in ovarian cancer remains unclear. In this study, we establish TUSC3 as a novel ovarian cancer tumor suppressor using a xenograft mouse model and demonstrate that loss of TUSC3 alters the molecular response to endoplasmic reticulum stress and induces hallmarks of the epithelial-to-mesenchymal transition in ovarian cancer cells. In summary, we have confirmed the tumor-suppressive function of TUSC3 and identified the possible mechanism driving TUSC3-deficient ovarian cancer cells toward a malignant phenotype.
ER -
KRATOCHVÍLOVÁ, Kateřina, Peter HORAK, Milan EŠNER, Karel SOUČEK, Dietmar PILS, Mariam ANEES, Erwin TOMASICH, František DRÁFI, Veronika JURTÍKOVÁ, Aleš HAMPL, Michael KRAINER and Petr VAŇHARA. Tumor suppressor candidate 3 (TUSC3) prevents the epithelialto- mesenchymal transition and inhibits tumor growth by modulating the endoplasmic reticulum stress response in ovarian cancer cells. \textit{International Journal of Cancer}. Hoboken: Wiley-Blackwell, 2015, vol.~137, No~6, p.~1330-1340. ISSN~0020-7136. Available from: https://dx.doi.org/10.1002/ijc.29502.
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