Detailed Information on Publication Record
2015
Fate of the Molar Dental Lamina in the Monophyodont Mouse
DOSEDĚLOVÁ, Hana, Jana DUMKOVÁ, Hervé LESOT, Kristýna GLOCOVÁ, Michaela KUNOVÁ et. al.Basic information
Original name
Fate of the Molar Dental Lamina in the Monophyodont Mouse
Authors
DOSEDĚLOVÁ, Hana (203 Czech Republic), Jana DUMKOVÁ (203 Czech Republic, belonging to the institution), Hervé LESOT (250 France), Kristýna GLOCOVÁ (203 Czech Republic), Michaela KUNOVÁ (203 Czech Republic, belonging to the institution), Abigail S. TUCKER (826 United Kingdom of Great Britain and Northern Ireland), Iva VESELÁ (203 Czech Republic), Pavel KREJČÍ (203 Czech Republic, belonging to the institution), František TICHÝ (203 Czech Republic), Aleš HAMPL (203 Czech Republic, belonging to the institution) and marcela BUCHTOVÁ (203 Czech Republic, guarantor, belonging to the institution)
Edition
Plos one, San Francisco, Public Library Science, 2015, 1932-6203
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
10600 1.6 Biological sciences
Country of publisher
United States of America
Confidentiality degree
není předmětem státního či obchodního tajemství
Impact factor
Impact factor: 3.057
RIV identification code
RIV/00216224:14310/15:00094512
Organization unit
Faculty of Science
UT WoS
000355183900107
Keywords in English
EPITHELIAL STEM-CELLS; TOOTH REPLACEMENT; ODONTOBLAST DIFFERENTIATION; BASAL LAMINA; TEETH; PROLIFERATION; HEDGEHOG; MORPHOGENESIS; DENTITION; SOX2
Tags
International impact, Reviewed
Změněno: 13/4/2018 15:29, Ing. Nicole Zrilić
Abstract
V originále
The successional dental lamina (SDL) plays an essential role in the development of replacement teeth in diphyodont and polyphyodont animals. A morphologically similar structure, the rudimental successional dental lamina (RSDL), has been described in monophyodont (only one tooth generation) lizards on the lingual side of the developing functional tooth. This rudimentary lamina regresses, which has been proposed to play a role in preventing the formation of future generations of teeth. A similar rudimentary lingual structure has been reported associated with the first molar in the monophyodont mouse, and we show that this structure is common to all murine molars. Intriguingly, a lingual lamina is also observed on the non-replacing molars of other diphyodont mammals (pig and hedgehog), initially appearing very similar to the successional dental lamina on the replacing teeth. We have analyzed the morphological as well as ultrastructural changes that occur during the development and loss of this molar lamina in the mouse, from its initiation at late embryonic stages to its disappearance at postnatal stages. We show that loss appears to be driven by a reduction in cell proliferation, down-regulation of the progenitor marker Sox2, with only a small number of cells undergoing programmed cell death. The lingual lamina was associated with the dental stalk, a short epithelial connection between the tooth germ and the oral epithelium. The dental stalk remained in contact with the oral epithelium throughout tooth development up to eruption when connective tissue and numerous capillaries progressively invaded the dental stalk. The buccal side of the dental stalk underwent keratinisation and became part of the gingival epithelium, while most of the lingual cells underwent programmed cell death and the tissue directly above the erupting tooth was shed into the oral cavity.
Links
| GB14-37368G, research and development project |
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