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@article{1306996,
author = {Sedláčková, Hana and Cechova, Barbora and Mlčoušková, Jarmila and Krejčí, Lumír},
article_location = {Amsterdam},
article_number = {"neuvedeno"},
doi = {http://dx.doi.org/10.1016/j.dnarep.2015.02.020},
keywords = {Genomic stability; Homologous recombination; RECQ4; DNA binding; Holliday junction},
language = {eng},
issn = {1568-7864},
journal = {DNA Repair},
title = {RECQ4 selectively recognizes Holliday junctions},
volume = {30},
year = {2015}
}
TY - JOUR
ID - 1306996
AU - Sedláčková, Hana - Cechova, Barbora - Mlčoušková, Jarmila - Krejčí, Lumír
PY - 2015
TI - RECQ4 selectively recognizes Holliday junctions
JF - DNA Repair
VL - 30
IS - "neuvedeno"
SP - 80-89
EP - 80-89
PB - ELSEVIER SCIENCE BV
SN - 15687864
KW - Genomic stability
KW - Homologous recombination
KW - RECQ4
KW - DNA binding
KW - Holliday junction
N2 - The RECQ4 protein belongs to the RecQ helicase family, which plays crucial roles in genome maintenance. Mutations in the RECQ4 gene are associated with three insidious hereditary disorders: Rothmund Thomson, Baller-Gerold, and RAPADILINO syndromes. These syndromes are characterized by growth deficiency, radial ray defects, red rashes, and higher predisposition to malignancy, especially osteosarcomas. Within the RecQ family, RECQ4 is the least characterized, and its role in DNA replication and repair remains unknown. We have identified several DNA binding sites within RECQ4. Two are located at the N-terminus and one is located within the conserved helicase domain. N-terminal domains probably cooperate with one another and promote the strong annealing activity of RECQ4. Surprisingly, the region spanning 322-400 aa shows a very high affinity for branched DNA substrates, especially Holliday junctions. This study demonstrates biochemical activities of RECQ4 that could be involved in genome maintenance and suggest its possible role in processing replication and recombination intermediates. (C) 2015 Elsevier B.V. All rights reserved.
ER -
SEDLÁČKOVÁ, Hana, Barbora CECHOVA, Jarmila MLČOUŠKOVÁ and Lumír KREJČÍ. RECQ4 selectively recognizes Holliday junctions. \textit{DNA Repair}. Amsterdam: ELSEVIER SCIENCE BV, 2015, vol.~30, ''neuvedeno'', p.~80-89. ISSN~1568-7864. Available from: https://dx.doi.org/10.1016/j.dnarep.2015.02.020.
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