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@article{1307113, author = {Růžek, Lukáš and Konecny, Tomas and Souček, Filip and Konecny, Dana and Mach, Lukáš and Ommen, Steve R. and Kopecky, Stephen L. and Nishimura, Rick A.}, article_location = {Bridgewater}, article_number = {4}, doi = {http://dx.doi.org/10.1016/j.amjcard.2015.05.022}, keywords = {Hypertrophic cardiomyopathy; male sexual dysfunction; phosphodiesterase type 5; sildenafil}, language = {eng}, issn = {0002-9149}, journal = {American Journal of Cardiology}, title = {Phosphodiesterase 5 Inhibitor Use in Men With Hypertrophic Cardiomyopathy}, url = {http://www.ajconline.org/article/S0002-9149(15)01346-6/abstract}, volume = {116}, year = {2015} }
TY - JOUR ID - 1307113 AU - Růžek, Lukáš - Konecny, Tomas - Souček, Filip - Konecny, Dana - Mach, Lukáš - Ommen, Steve R. - Kopecky, Stephen L. - Nishimura, Rick A. PY - 2015 TI - Phosphodiesterase 5 Inhibitor Use in Men With Hypertrophic Cardiomyopathy JF - American Journal of Cardiology VL - 116 IS - 4 SP - 618-621 EP - 618-621 PB - Excerpta Medica Inc-Elsevier Science Inc SN - 00029149 KW - Hypertrophic cardiomyopathy KW - male sexual dysfunction KW - phosphodiesterase type 5 KW - sildenafil UR - http://www.ajconline.org/article/S0002-9149(15)01346-6/abstract L2 - http://www.ajconline.org/article/S0002-9149(15)01346-6/abstract N2 - The prevalence of sexual dysfunction (SD) in men with hypertrophic cardiomyopathy (HC) remains unknown, yet its clinical relevance may be high given that its treatment- phosphodiesterase 5 inhibitors (PDE5i)-can increase the left ventricular outflow tract pressure gradient. In this retrospective study, we evaluated the medical records of consecutively seen men with HC for the evidence of SD (defined as SD diagnosis noted in the medical record, the use of medications unique for SD, or SD reported by the patient on a routine clinical questionnaire). Of the 283 consecutively seen men with HC (mean age 52.9 +/- 14.1 years), 63 patients (22%) with SD were identified. Of those with SD, 38% were recorded as regularly using PDE5i. In conclusion, SD and the use of PDE5i present a relatively common occurrence in men with HC, and further studies are needed to develop an evidence-guided algorithm for safe implementation of SD therapies in this most common inherited cardiomyopathy. ER -
RŮŽEK, Lukáš, Tomas KONECNY, Filip SOUČEK, Dana KONECNY, Lukáš MACH, Steve R. OMMEN, Stephen L. KOPECKY and Rick A. NISHIMURA. Phosphodiesterase 5 Inhibitor Use in Men With Hypertrophic Cardiomyopathy. \textit{American Journal of Cardiology}. Bridgewater: Excerpta Medica Inc-Elsevier Science Inc, 2015, vol.~116, No~4, p.~618-621. ISSN~0002-9149. Available from: https://dx.doi.org/10.1016/j.amjcard.2015.05.022.
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