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@article{1307935,
author = {Trizuljak, Jakub and Srovnal, Josef and Plevová, Karla and Brychtová, Yvona and Semerád, Lukáš and Bakešová, Denisa and Létalová, Eva and Benedíková, Andrea and Mayer, Jiří and Hajdúch, Marian and Pospíšilová, Šárka and Doubek, Michael},
article_location = {Dallas},
article_number = {7},
doi = {http://dx.doi.org/10.1016/j.clml.2015.02.003},
keywords = {Chronic lymphocytic leukemia; Merkel cell polyomavirus; Overall survival; Polymerase chain reaction; Prognostic factors},
language = {eng},
issn = {2152-2650},
journal = {Clinical Lymphoma Myeloma & Leukemia},
title = {Analysis of Prognostic Significance of Merkel Cell Polyomavirus in Chronic Lymphocytic Leukemia},
url = {http://ac.els-cdn.com/S2152265015000324/1-s2.0-S2152265015000324-main.pdf?_tid=35610b90-3b65-11e5-9c14-00000aacb35d&acdnat=1438774338_b787fb4ae3f955d7a6bbe61376e2b860},
volume = {15},
year = {2015}
}
TY - JOUR
ID - 1307935
AU - Trizuljak, Jakub - Srovnal, Josef - Plevová, Karla - Brychtová, Yvona - Semerád, Lukáš - Bakešová, Denisa - Létalová, Eva - Benedíková, Andrea - Mayer, Jiří - Hajdúch, Marian - Pospíšilová, Šárka - Doubek, Michael
PY - 2015
TI - Analysis of Prognostic Significance of Merkel Cell Polyomavirus in Chronic Lymphocytic Leukemia
JF - Clinical Lymphoma Myeloma & Leukemia
VL - 15
IS - 7
SP - 439-442
EP - 439-442
PB - Cig Media Group
SN - 21522650
KW - Chronic lymphocytic leukemia
KW - Merkel cell polyomavirus
KW - Overall survival
KW - Polymerase chain reaction
KW - Prognostic factors
UR - http://ac.els-cdn.com/S2152265015000324/1-s2.0-S2152265015000324-main.pdf?_tid=35610b90-3b65-11e5-9c14-00000aacb35d&acdnat=1438774338_b787fb4ae3f955d7a6bbe61376e2b860
N2 - Merkel cell polyomavirus (MCPyV) has been found to be associated with chronic lymphocytic leukemia (CLL). We evaluated its prognostic significance in CLL. MCPyV occurrence seems to be a relatively rare event during the course of CLL. MCPyV is also unlikely to influence the outcome of CLL patients. Background: Merkel cell polyomavirus (MCPyV), a ubiquitous DNA tumor virus, has been found to be associated with Merkel cell carcinoma and chronic lymphocytic leukemia (CLL). Previous studies have reported conflicting results on the frequency and potential pathogenetic role of MCPyV in CLL. The aim of this study was to evaluate MCPyV's association with CLL and its prognostic significance. Patients and Methods: Between 2006 and 2013, DNA samples obtained from CLL patients (n = 119) before treatment were tested for MCPyV using quantitative real-time polymerase chain reaction analysis and verified by gel electrophoresis. Only samples testing positive by both methods were considered valid. Results: We found that 13 (11%) of 119 CLL cases were positive for MCPyV. Between the groups of MCPyV-positive and -negative patients, there was no significant difference in the sex, age, cytogenetics, presence of p53 defect, or immunoglobulin heavy chain (IGHV) mutational status. In the subset of MCPyV-negative patients, advanced Rai stage (III to IV) was found more frequently, and therapy was initiated more often. There was no difference in overall response rate, median progression-free survival, and overall survival between both groups. We did not observe any new positivity after treatment in initially MCPyV-negative patients. Conclusion: This study provides the first analysis of the prognostic role of MCPyV in CLL. MCPyV occurrence seems to be a relatively rare event during the course of CLL. MCPyV is also unlikely to influence the outcome of CLL patients.
ER -
TRIZULJAK, Jakub, Josef SROVNAL, Karla PLEVOVÁ, Yvona BRYCHTOVÁ, Lukáš SEMERÁD, Denisa BAKEŠOVÁ, Eva LÉTALOVÁ, Andrea BENEDÍKOVÁ, Jiří MAYER, Marian HAJDÚCH, Šárka POSPÍŠILOVÁ a Michael DOUBEK. Analysis of Prognostic Significance of Merkel Cell Polyomavirus in Chronic Lymphocytic Leukemia. \textit{Clinical Lymphoma Myeloma \&{} Leukemia}. Dallas: Cig Media Group, 2015, roč.~15, č.~7, s.~439-442. ISSN~2152-2650. Dostupné z: https://dx.doi.org/10.1016/j.clml.2015.02.003.
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