Analysis of Prognostic Significance of Merkel Cell Polyomavirus
in Chronic Lymphocytic Leukemia

J 2015

Analysis of Prognostic Significance of Merkel Cell Polyomavirus in Chronic Lymphocytic Leukemia

TRIZULJAK, Jakub, Josef SROVNAL, Karla PLEVOVÁ, Yvona BRYCHTOVÁ, Lukáš SEMERÁD et. al.

Basic information

Original name

Analysis of Prognostic Significance of Merkel Cell Polyomavirus in Chronic Lymphocytic Leukemia

Authors

TRIZULJAK, Jakub (703 Slovakia, guarantor, belonging to the institution), Josef SROVNAL (203 Czech Republic), Karla PLEVOVÁ (203 Czech Republic, belonging to the institution), Yvona BRYCHTOVÁ (203 Czech Republic, belonging to the institution), Lukáš SEMERÁD (203 Czech Republic, belonging to the institution), Denisa BAKEŠOVÁ (703 Slovakia, belonging to the institution), Eva LÉTALOVÁ (203 Czech Republic, belonging to the institution), Andrea BENEDÍKOVÁ (203 Czech Republic), Jiří MAYER (203 Czech Republic, belonging to the institution), Marian HAJDÚCH (203 Czech Republic), Šárka POSPÍŠILOVÁ (203 Czech Republic, belonging to the institution) and Michael DOUBEK (203 Czech Republic, belonging to the institution)

Edition

Clinical Lymphoma Myeloma & Leukemia, Dallas, Cig Media Group, 2015, 2152-2650

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30200 3.2 Clinical medicine

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 2.316

RIV identification code

RIV/00216224:14110/15:00083517

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1016/j.clml.2015.02.003

UT WoS

000357967700010

Keywords in English

Chronic lymphocytic leukemia; Merkel cell polyomavirus; Overall survival; Polymerase chain reaction; Prognostic factors

Abstract

V originále

Merkel cell polyomavirus (MCPyV) has been found to be associated with chronic lymphocytic leukemia (CLL). We evaluated its prognostic significance in CLL. MCPyV occurrence seems to be a relatively rare event during the course of CLL. MCPyV is also unlikely to influence the outcome of CLL patients. Background: Merkel cell polyomavirus (MCPyV), a ubiquitous DNA tumor virus, has been found to be associated with Merkel cell carcinoma and chronic lymphocytic leukemia (CLL). Previous studies have reported conflicting results on the frequency and potential pathogenetic role of MCPyV in CLL. The aim of this study was to evaluate MCPyV's association with CLL and its prognostic significance. Patients and Methods: Between 2006 and 2013, DNA samples obtained from CLL patients (n = 119) before treatment were tested for MCPyV using quantitative real-time polymerase chain reaction analysis and verified by gel electrophoresis. Only samples testing positive by both methods were considered valid. Results: We found that 13 (11%) of 119 CLL cases were positive for MCPyV. Between the groups of MCPyV-positive and -negative patients, there was no significant difference in the sex, age, cytogenetics, presence of p53 defect, or immunoglobulin heavy chain (IGHV) mutational status. In the subset of MCPyV-negative patients, advanced Rai stage (III to IV) was found more frequently, and therapy was initiated more often. There was no difference in overall response rate, median progression-free survival, and overall survival between both groups. We did not observe any new positivity after treatment in initially MCPyV-negative patients. Conclusion: This study provides the first analysis of the prognostic role of MCPyV in CLL. MCPyV occurrence seems to be a relatively rare event during the course of CLL. MCPyV is also unlikely to influence the outcome of CLL patients.

Links

ED1.1.00/02.0068, research and development project

Name: CEITEC - central european institute of technology

EE2.3.20.0045, research and development project

Name: Podpora profesního růstu a mezinárodní integrace výzkumných týmů v oblasti molekulární medicíny

NT13493, research and development project

Name: Molekulární charakterizace B buněčných receptorů a jejich vztah k evoluci genetických změn u chronické lymfocytární leukémie

7E13008, research and development project

Name: Next Generation Sequencing Platform for Targeted Personalized Therapy of Leukemia (Acronym: NGS-PTL)

Investor: Ministry of Education, Youth and Sports of the CR

Citovat

TRIZULJAK, Jakub, Josef SROVNAL, Karla PLEVOVÁ, Yvona BRYCHTOVÁ, Lukáš SEMERÁD, Denisa BAKEŠOVÁ, Eva LÉTALOVÁ, Andrea BENEDÍKOVÁ, Jiří MAYER, Marian HAJDÚCH, Šárka POSPÍŠILOVÁ and Michael DOUBEK. Analysis of Prognostic Significance of Merkel Cell Polyomavirus in Chronic Lymphocytic Leukemia. Clinical Lymphoma Myeloma & Leukemia. Dallas: Cig Media Group, 2015, vol. 15, No 7, p. 439-442. ISSN 2152-2650. Available from: https://dx.doi.org/10.1016/j.clml.2015.02.003.

@article{1307935,
   author = {Trizuljak, Jakub and Srovnal, Josef and Plevová, Karla and Brychtová, Yvona and Semerád, Lukáš and Bakešová, Denisa and Létalová, Eva and Benedíková, Andrea and Mayer, Jiří and Hajdúch, Marian and Pospíšilová, Šárka and Doubek, Michael},
   article_location = {Dallas},
   article_number = {7},
   doi = {http://dx.doi.org/10.1016/j.clml.2015.02.003},
   keywords = {Chronic lymphocytic leukemia; Merkel cell polyomavirus; Overall survival; Polymerase chain reaction; Prognostic factors},
   language = {eng},
   issn = {2152-2650},
   journal = {Clinical Lymphoma Myeloma & Leukemia},
   title = {Analysis of Prognostic Significance of Merkel Cell Polyomavirus in Chronic Lymphocytic Leukemia},
   url = {http://ac.els-cdn.com/S2152265015000324/1-s2.0-S2152265015000324-main.pdf?_tid=35610b90-3b65-11e5-9c14-00000aacb35d&acdnat=1438774338_b787fb4ae3f955d7a6bbe61376e2b860},
   volume = {15},
   year = {2015}
}

TY  - JOUR
ID  - 1307935
AU  - Trizuljak, Jakub - Srovnal, Josef - Plevová, Karla - Brychtová, Yvona - Semerád, Lukáš - Bakešová, Denisa - Létalová, Eva - Benedíková, Andrea - Mayer, Jiří - Hajdúch, Marian - Pospíšilová, Šárka - Doubek, Michael
PY  - 2015
TI  - Analysis of Prognostic Significance of Merkel Cell Polyomavirus in Chronic Lymphocytic Leukemia
JF  - Clinical Lymphoma Myeloma & Leukemia
VL  - 15
IS  - 7
SP  - 439-442
EP  - 439-442
PB  - Cig Media Group
SN  - 21522650
KW  - Chronic lymphocytic leukemia
KW  - Merkel cell polyomavirus
KW  - Overall survival
KW  - Polymerase chain reaction
KW  - Prognostic factors
UR  - http://ac.els-cdn.com/S2152265015000324/1-s2.0-S2152265015000324-main.pdf?_tid=35610b90-3b65-11e5-9c14-00000aacb35d&acdnat=1438774338_b787fb4ae3f955d7a6bbe61376e2b860
N2  - Merkel cell polyomavirus (MCPyV) has been found to be associated with chronic lymphocytic leukemia (CLL). We evaluated its prognostic significance in CLL. MCPyV occurrence seems to be a relatively rare event during the course of CLL. MCPyV is also unlikely to influence the outcome of CLL patients. Background: Merkel cell polyomavirus (MCPyV), a ubiquitous DNA tumor virus, has been found to be associated with Merkel cell carcinoma and chronic lymphocytic leukemia (CLL). Previous studies have reported conflicting results on the frequency and potential pathogenetic role of MCPyV in CLL. The aim of this study was to evaluate MCPyV's association with CLL and its prognostic significance. Patients and Methods: Between 2006 and 2013, DNA samples obtained from CLL patients (n = 119) before treatment were tested for MCPyV using quantitative real-time polymerase chain reaction analysis and verified by gel electrophoresis. Only samples testing positive by both methods were considered valid. Results: We found that 13 (11%) of 119 CLL cases were positive for MCPyV. Between the groups of MCPyV-positive and -negative patients, there was no significant difference in the sex, age, cytogenetics, presence of p53 defect, or immunoglobulin heavy chain (IGHV) mutational status. In the subset of MCPyV-negative patients, advanced Rai stage (III to IV) was found more frequently, and therapy was initiated more often. There was no difference in overall response rate, median progression-free survival, and overall survival between both groups. We did not observe any new positivity after treatment in initially MCPyV-negative patients. Conclusion: This study provides the first analysis of the prognostic role of MCPyV in CLL. MCPyV occurrence seems to be a relatively rare event during the course of CLL. MCPyV is also unlikely to influence the outcome of CLL patients.
ER  -

TRIZULJAK, Jakub, Josef SROVNAL, Karla PLEVOVÁ, Yvona BRYCHTOVÁ, Lukáš SEMERÁD, Denisa BAKEŠOVÁ, Eva LÉTALOVÁ, Andrea BENEDÍKOVÁ, Jiří MAYER, Marian HAJDÚCH, Šárka POSPÍŠILOVÁ and Michael DOUBEK. Analysis of Prognostic Significance of Merkel Cell Polyomavirus in Chronic Lymphocytic Leukemia. \textit{Clinical Lymphoma Myeloma \&{} Leukemia}. Dallas: Cig Media Group, 2015, vol.~15, No~7, p.~439-442. ISSN~2152-2650. Available from: https://dx.doi.org/10.1016/j.clml.2015.02.003.

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