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@article{1307985,
author = {Balounova, Z. and Březina, Vítězslav and Susterova, K. and Rajchard, J.},
article_location = {Prague},
article_number = {3},
doi = {http://dx.doi.org/10.17221/8060-VETMED},
keywords = {bryozoan; cell line L929; spreading; specific growth rate; cell proliferation; time-lapse cinemicrography; bio-active substances},
language = {eng},
issn = {0375-8427},
journal = {Veterinarni Medicina},
title = {Primary screening of potentially bio-active substances in the lyophilisate of Pectinatella magnifica biomass},
volume = {60},
year = {2015}
}
TY - JOUR
ID - 1307985
AU - Balounova, Z. - Březina, Vítězslav - Susterova, K. - Rajchard, J.
PY - 2015
TI - Primary screening of potentially bio-active substances in the lyophilisate of Pectinatella magnifica biomass
JF - Veterinarni Medicina
VL - 60
IS - 3
SP - 141-146
EP - 141-146
PB - CZECH ACAD AGRIC SCI
SN - 03758427
KW - bryozoan
KW - cell line L929
KW - spreading
KW - specific growth rate
KW - cell proliferation
KW - time-lapse cinemicrography
KW - bio-active substances
N2 - The purpose of this research was to examine potential bio-active substances in the lyophilisate of Pectinatella magnifica biomass and its focus was on primary screening of the biomass. Extracts of lyophilisate were applied to murine cells and their effects on cell population growth, cell morphology and cell distribution were monitored. The inhibition of cytoskeleton repair reached its maximum after a 24-h exposure of the cells to the extract prepared at a temperature of 37 degrees C, whereas the 1-h application of the extract leached at a temperature of 37 degrees C resulted in quick repair of cytoskeletal function. When compared with the control, in which no extract was applied, the application of all treatments of the extract reduced the time needed for the duplication of cells. The lowest growth rate was found in the cells in the extract prepared at 37 degrees C for 24 h. The mitotic activity reached its maximum when using the extract prepared at degrees C for 1 h. Under such conditions, the process of cell duplication was even faster than in the control sample, while it was the slowest using the extract prepared at 37 degrees C for 24 h. The study of potential biologically active substances of Pectinatella magnifica is highly topical due to the frequent occurrence of this organism in the water-supply and recreational reservoirs.
ER -
BALOUNOVA, Z., Vítězslav BŘEZINA, K. SUSTEROVA and J. RAJCHARD. Primary screening of potentially bio-active substances in the lyophilisate of Pectinatella magnifica biomass. \textit{Veterinarni Medicina}. Prague: CZECH ACAD AGRIC SCI, 2015, vol.~60, No~3, p.~141-146. ISSN~0375-8427. Available from: https://dx.doi.org/10.17221/8060-VETMED.
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