LANGOVÁ, Petra, Jan ŠTEMBÍREK, Martina POKORNÁ, Michal NAVRÁTIL, Eva MATALOVÁ and marcela BUCHTOVÁ. Surgical Methods in Mouse Tooth Autotransplantation Research. In IBMS BoneKEy 13, The 4th Joint Meeting of ECTS and IBMS. 2015. ISSN 1940-8692. Available from: https://dx.doi.org/10.1038/bonekey.2015.53.
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Basic information
Original name Surgical Methods in Mouse Tooth Autotransplantation Research
Name in Czech Chirurgické metody při výzkumu autotransplantace zubů u myší
Authors LANGOVÁ, Petra, Jan ŠTEMBÍREK, Martina POKORNÁ, Michal NAVRÁTIL, Eva MATALOVÁ and marcela BUCHTOVÁ.
Edition IBMS BoneKEy 13, The 4th Joint Meeting of ECTS and IBMS, 2015.
Other information
Original language English
Type of outcome Conference abstract
Field of Study 30200 3.2 Clinical medicine
Country of publisher Netherlands
Confidentiality degree is not subject to a state or trade secret
Organization unit Faculty of Medicine
ISSN 1940-8692
Doi http://dx.doi.org/10.1038/bonekey.2015.53
Keywords (in Czech) ankylóza, reinervace, revaskularizace
Keywords in English ankylosis, reinnervation, revascularisation
Changed by Changed by: Ing. Mgr. Věra Pospíšilíková, učo 9005. Changed: 31/8/2015 12:29.
Abstract
Autotransplantation of teeth is one of the possibilities to substitute the missing teeth in the dental arch. In comparison with prosthetic dentistry and implantology, autogenous transplantation is the most natural way of tooth replacement. Although success and advantages are prevailing, there are some complications like ankylosis or inflammation, which have to be solved. To understand regenerative processes after autotransplantations, several animal models and histological/molecular methods have been established. We review recent achievements in autotransplantation techniques with using animal models and the evaluation of advantages and disadvantages of their using as showed also in our experiments. The most common laboratory animals used in autotransplantation research are mice and rats. Despite the monophyodont dentition and reduced dental formula together with hypsodont incisors and toothless diastema, numerous findings can be successfully extrapolated from rodents to humans. Various parameters of successful autotransplantation such as periodontal tissue regeneration, reinnervation or revascularisation have already been proved in the mouse. The autotransplantation of teeth currently has a firm place in the field of dentistry because of preserving the physiological properties of teeth, periodontal and alveolar bone.
Abstract (in Czech)
Autotransplantace zubů je jednou z možností, jak v zubním oblouku nahradit chybějící zuby. Tato metoda je oproti protetickému či implantologickému řešení přirozenou cestou náhrady chrupu. Ačkoli převažují výhody a úspěch, setkáváme se při operacích i s komplikacemi, které musejí být následně řešeny, jako jsou ankylóza nebo zánět. To understand regenerative processes after autotransplantations, several animal models and histological/molecular methods have been established. We review recent achievements in autotransplantation techniques with using animal models and the evaluation of advantages and disadvantages of their using as showed also in our experiments. The most common laboratory animals used in autotransplantation research are mice and rats. Despite the monophyodont dentition and reduced dental formula together with hypsodont incisors and toothless diastema, numerous findings can be successfully extrapolated from rodents to humans. Various parameters of successful autotransplantation such as periodontal tissue regeneration, reinnervation or revascularisation have already been proved in the mouse. The autotransplantation of teeth currently has a firm place in the field of dentistry because of preserving the physiological properties of teeth, periodontal and alveolar bone.
Links
NT11420, research and development projectName: Molekulární diagnostika hypodoncie a možnosti zubních autotransplantací
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