Hematopoiesis in 5-Fluorouracil-Treated Adenosine A(3) Receptor
Knock-Out Mice

J 2015

Hematopoiesis in 5-Fluorouracil-Treated Adenosine A(3) Receptor Knock-Out Mice

HOFER, M., M. POSPÍŠIL, Ladislav DUŠEK, Z. HOFEROVÁ, D. KOMŮRKOVÁ et. al.

Basic information

Original name

Hematopoiesis in 5-Fluorouracil-Treated Adenosine A(3) Receptor Knock-Out Mice

Authors

HOFER, M. (203 Czech Republic), M. POSPÍŠIL (203 Czech Republic), Ladislav DUŠEK (203 Czech Republic, belonging to the institution), Z. HOFEROVÁ (203 Czech Republic) and D. KOMŮRKOVÁ (203 Czech Republic, guarantor)

Edition

Physiological Research, Praha, Institute of Physiology, Academy of Sciences of the Czech Republic, 2015, 0862-8408

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30105 Physiology

Country of publisher

Czech Republic

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 1.643

RIV identification code

RIV/00216224:14110/15:00083581

Organization unit

Faculty of Medicine

UT WoS

000357409400013

Keywords in English

Adenosine A(3) receptor knock-out mice; Hematopoiesis; 5-fluorouracil-induced hematotoxicity

Abstract

V originále

The purpose of the study was to describe and compare normal and 5-fluorouracil (5-FU)-suppressed hematopoiesis in adenosine A(3) receptor knock-out (A(3)AR KO) mice and their wild-type (WT) counterparts. To meet the purpose, a complex hematological analysis comprising nineteen peripheral blood and bone marrow parameters was performed in the mice. Defects previously observed in the peripheral blood erythrocyte and thrombocyte parameters of the A3AR KO mice were confirmed. Compartments of the bone marrow progenitor cells for granulocytes/macrophages and erythrocytes were enhanced in the control, as well as in the 5-FU-administered A3AR KO mice. 5-FU-induced hematopoietic suppression, evaluated on day 2 after the administration of the cytotoxic drug, was found to be significantly deeper in the A3AR KO mice compared with their WT counterparts, as measured at the level of the bone marrow progenitor cells. The rate of regeneration, as assessed between days 2 and 7 after 5-FU administration, was observed in the population of the granulocyte/macrophage progenitor cells to be higher in the A3AR KO mice in comparison with the WT ones. The increased depth of 5-FU-induced suppression in the compartments of the hematopoietic progenitor cells in the A3AR KO mice represents probably a hitherto undescribed further consequence of the lack of adenosine A3 receptors and indicates its synergism with the pharmacologically induced cytotoxic action of 5-FU.

Citovat

HOFER, M., M. POSPÍŠIL, Ladislav DUŠEK, Z. HOFEROVÁ and D. KOMŮRKOVÁ. Hematopoiesis in 5-Fluorouracil-Treated Adenosine A(3) Receptor Knock-Out Mice. Physiological Research. Praha: Institute of Physiology, Academy of Sciences of the Czech Republic, 2015, vol. 64, No 2, p. 255-262. ISSN 0862-8408.

@article{1308715,
   author = {Hofer, M. and Pospíšil, M. and Dušek, Ladislav and Hoferová, Z. and Komůrková, D.},
   article_location = {Praha},
   article_number = {2},
   keywords = {Adenosine A(3) receptor knock-out mice; Hematopoiesis; 5-fluorouracil-induced hematotoxicity},
   language = {eng},
   issn = {0862-8408},
   journal = {Physiological Research},
   title = {Hematopoiesis in 5-Fluorouracil-Treated Adenosine A(3) Receptor Knock-Out Mice},
   volume = {64},
   year = {2015}
}

TY  - JOUR
ID  - 1308715
AU  - Hofer, M. - Pospíšil, M. - Dušek, Ladislav - Hoferová, Z. - Komůrková, D.
PY  - 2015
TI  - Hematopoiesis in 5-Fluorouracil-Treated Adenosine A(3) Receptor Knock-Out Mice
JF  - Physiological Research
VL  - 64
IS  - 2
SP  - 255-262
EP  - 255-262
PB  - Institute of Physiology, Academy of Sciences of the Czech Republic
SN  - 08628408
KW  - Adenosine A(3) receptor knock-out mice
KW  - Hematopoiesis
KW  - 5-fluorouracil-induced hematotoxicity
N2  - The purpose of the study was to describe and compare normal and 5-fluorouracil (5-FU)-suppressed hematopoiesis in adenosine A(3) receptor knock-out (A(3)AR KO) mice and their wild-type (WT) counterparts. To meet the purpose, a complex hematological analysis comprising nineteen peripheral blood and bone marrow parameters was performed in the mice. Defects previously observed in the peripheral blood erythrocyte and thrombocyte parameters of the A3AR KO mice were confirmed. Compartments of the bone marrow progenitor cells for granulocytes/macrophages and erythrocytes were enhanced in the control, as well as in the 5-FU-administered A3AR KO mice. 5-FU-induced hematopoietic suppression, evaluated on day 2 after the administration of the cytotoxic drug, was found to be significantly deeper in the A3AR KO mice compared with their WT counterparts, as measured at the level of the bone marrow progenitor cells. The rate of regeneration, as assessed between days 2 and 7 after 5-FU administration, was observed in the population of the granulocyte/macrophage progenitor cells to be higher in the A3AR KO mice in comparison with the WT ones. The increased depth of 5-FU-induced suppression in the compartments of the hematopoietic progenitor cells in the A3AR KO mice represents probably a hitherto undescribed further consequence of the lack of adenosine A3 receptors and indicates its synergism with the pharmacologically induced cytotoxic action of 5-FU.
ER  -

HOFER, M., M. POSPÍŠIL, Ladislav DUŠEK, Z. HOFEROVÁ and D. KOMŮRKOVÁ. Hematopoiesis in 5-Fluorouracil-Treated Adenosine A(3) Receptor Knock-Out Mice. \textit{Physiological Research}. Praha: Institute of Physiology, Academy of Sciences of the Czech Republic, 2015, vol.~64, No~2, p.~255-262. ISSN~0862-8408.

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