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@proceedings{1311047,
author = {Kolářová, Lenka and Hajtmanová, Kristína and Kučera, Lukáš and Vaňhara, Petr and Peňa Mendéz, Eladia Maria and Conde, Josse Elias and Hampl, Aleš and Havel, Josef},
booktitle = {67. zjazd chemikov, 7-11 September 2015, High Tatras, Slovak Republic. No. 1Po08},
keywords = {metal-organic frameworks; matrix; mass spectrometry},
language = {eng},
title = {Metal-organic frameworks as matrices for mass spectrometry of biomolecules},
year = {2015}
}
TY - CONF
ID - 1311047
AU - Kolářová, Lenka - Hajtmanová, Kristína - Kučera, Lukáš - Vaňhara, Petr - Peňa Mendéz, Eladia Maria - Conde, Josse Elias - Hampl, Aleš - Havel, Josef
PY - 2015
TI - Metal-organic frameworks as matrices for mass spectrometry of biomolecules
KW - metal-organic frameworks
KW - matrix
KW - mass spectrometry
N2 - Metal-Organic Frameworks (MOFs) belong among new hybrid nanomaterials with porous structure consisting of a framework of metal ions and organic ligands. These coordination polymers with unique properties, such as large surface area, tunable pore size, high porosity and high absorption capability in UV-visible range, make MOFs very prospective material in many diverse applications like adsorption of dyes, gas storage, gas separation, catalysis, drug storage and delivery, imaging, sensing, and as matrices in mass spectrometry [1, 2]. In this work, possibilities of MOFs, e.g. benzene-tricarboxylic acid and Cu2+ ions framework (HKUST-1, Fig. 1), to be used as possible matrices for mass spectrometry of various kinds of molecules from a simple (retinoic acid) to complex (peptides/proteins of mouse embryonic fibroblast) were examined. Either MOFs alone or in combination with classical MALDI matrices like dihydroxybenzoic acid, gold nanoparticles or other nanoparticles were extensively studied for Matrix and Surface Assisted Laser Desorption Ionization (MALDI and SALDI). It was found that, HKUST-1 is capable of increasing the ionization and MS detection of simple organic and/or various bio-molecules. The use of MOFs presents several advantages, including lower interference of background, salt tolerance, high sensitivity and reproducibility. Further potential use MOFs might be as a concentration probe and/or staining agents, for example.
ER -
KOLÁŘOVÁ, Lenka, Kristína HAJTMANOVÁ, Lukáš KUČERA, Petr VAŇHARA, Eladia Maria PEŇA MENDÉZ, Josse Elias CONDE, Aleš HAMPL a Josef HAVEL. Metal-organic frameworks as matrices for mass spectrometry of biomolecules. In \textit{67. zjazd chemikov, 7-11 September 2015, High Tatras, Slovak Republic. No. 1Po08}. 2015. ISSN~1336-7242.
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