Copper complexes of 6-aminopurine and 6-benzylaminopurine in
aqueous methanol solutions

D 2015

Copper complexes of 6-aminopurine and 6-benzylaminopurine in aqueous methanol solutions

PILAŘOVÁ, Iveta, Libuše TRNKOVÁ, Rudolf NAVRÁTIL and Přemysl LUBAL

Basic information

Original name

Copper complexes of 6-aminopurine and 6-benzylaminopurine in aqueous methanol solutions

Authors

PILAŘOVÁ, Iveta, Libuše TRNKOVÁ, Rudolf NAVRÁTIL and Přemysl LUBAL

Edition

Brno, 6th French - Czech "Vltava" Chemistry Meeting, p. 45 -45, 1 pp. 2015

Publisher

Masarykova univerzita

Other information

Language

English

Type of outcome

Stať ve sborníku

Field of Study

10403 Physical chemistry

Country of publisher

Czech Republic

Confidentiality degree

není předmětem státního či obchodního tajemství

Publication form

printed version "print"

Organization unit

Faculty of Science

ISBN

978-80-210-7934-2

Keywords (in Czech)

6-aminopurin; 6-benzylaminopurin; komplexy mědi; protonační konstanta; konstanta stability; potenciometrická titrace; iontově - selektivní elektroda

Keywords in English

6-aminopurine; 6-benzylaminopurine; copper complexes; protonation constant; stability constant; potentiometric titration; ion-selective electrode

Abstract

V originále

In order to follow many biological processes it is important to understand the interactions between nucleic acids and their constituents with metal ions. It is known that adenine shows various probabilities of coordination with transition metal ions due to its potential donor sites. Electronically favoured coordination sites N(1) and N(3) for the metals were added by the nitrogens N(3) and N(9) due to tautomerization of the imidazole hydrogen atom between N(7) and N(9). In this contribution the protonation and stability constants of 6-aminopurine )adenine) or 6-benzylaminopurine (BAP) and their copper complexes were determined potentiometrically by using the titrator Titrando 835 controlled by tiamo 1.2 (Metrohm, Switzerland). The experiemnts were hampered by BAP solubility and all the potentiometric experimets were conducted in aqueous methanol solutions (10% v/v CH3OH in water). The stability constants of the copper complexes were calculated for different ligand (purine):metal (copper) ratios according to the Sigel procedure. Potentiometric titrations at different temperature and at the same ionic strength (0.1 M NaCl) enabled the thermodynamic evaluation of changes in enthalpy and entropy of the complexation process. The temperature icrease leads to a decrease in the values of the stability constants suggesting an exothermic behaviour for the complexation process. On the base of thermodynamic data obtained for adenine and BAP the differences were attributed to the effect of the benzyl moiety.

Links

LH13053, research and development project

Name: Chemická a elektrochemická analýza purinových derivátů a jejich komplexů s mědí (Acronym: CECAP)

Investor: Ministry of Education, Youth and Sports of the CR

MUNI/A/1452/2014, interní kód MU

Name: Vývoj metod a instrumentace pro analýzu biologicky významných látek 2015

Investor: Masaryk University, Category A

Citovat

PILAŘOVÁ, Iveta, Libuše TRNKOVÁ, Rudolf NAVRÁTIL and Přemysl LUBAL. Copper complexes of 6-aminopurine and 6-benzylaminopurine in aqueous methanol solutions. In Ctibor Mazal, Přemysl Lubal, Miroslava Bittová. 6th French - Czech "Vltava" Chemistry Meeting. Brno: Masarykova univerzita, 2015, p. 45 -45. ISBN 978-80-210-7934-2.

@inproceedings{1312577,
   author = {Pilařová, Iveta and Trnková, Libuše and Navrátil, Rudolf and Lubal, Přemysl},
   address = {Brno},
   booktitle = {6th French - Czech "Vltava" Chemistry Meeting},
   editor = {Ctibor Mazal, Přemysl Lubal, Miroslava Bittová},
   keywords = {6-aminopurine; 6-benzylaminopurine; copper complexes; protonation constant; stability constant; potentiometric titration; ion-selective electrode},
   howpublished = {tištěná verze "print"},
   language = {eng},
   location = {Brno},
   isbn = {978-80-210-7934-2},
   note = {Nepřenášet do RIV - není na WoS ani Scopus, neodpovídá definici druhů výsledků dle M17+},
   pages = {45 -45},
   publisher = {Masarykova univerzita},
   title = {Copper complexes of 6-aminopurine and 6-benzylaminopurine in aqueous methanol solutions},
   year = {2015}
}

TY  - JOUR
ID  - 1312577
AU  - Pilařová, Iveta - Trnková, Libuše - Navrátil, Rudolf - Lubal, Přemysl
PY  - 2015
TI  - Copper complexes of 6-aminopurine and 6-benzylaminopurine in aqueous methanol solutions
PB  - Masarykova univerzita
CY  - Brno
SN  - 9788021079342
N1  - Nepřenášet do RIV - není na WoS ani Scopus, neodpovídá definici druhů výsledků dle M17+
KW  - 6-aminopurine
KW  - 6-benzylaminopurine
KW  - copper complexes
KW  - protonation constant
KW  - stability constant
KW  - potentiometric titration
KW  - ion-selective electrode
N2  - In order to follow many biological processes it is important to understand the interactions between nucleic acids and their constituents with metal ions. It is known that adenine shows various probabilities of coordination with transition metal ions due to its potential donor sites. Electronically favoured coordination sites N(1) and N(3) for the metals were added by the nitrogens N(3) and N(9) due to tautomerization of the imidazole hydrogen atom between N(7) and N(9). In this contribution the protonation and stability constants of 6-aminopurine )adenine) or 6-benzylaminopurine (BAP) and their copper complexes were determined potentiometrically by using the titrator Titrando 835 controlled by tiamo 1.2 (Metrohm, Switzerland). The experiemnts were hampered by BAP solubility and all the potentiometric experimets were conducted in aqueous methanol solutions (10% v/v CH3OH in water). The stability constants of the copper complexes were calculated for different ligand (purine):metal (copper) ratios according to the Sigel procedure. Potentiometric titrations at different temperature and at the same ionic strength (0.1 M NaCl) enabled the thermodynamic evaluation of changes in enthalpy and entropy of the complexation process. The temperature icrease leads to a decrease in the values of the stability constants suggesting an exothermic behaviour for the complexation process. On the base of thermodynamic data obtained for adenine and BAP the differences were attributed to the effect of the benzyl moiety.
ER  -

PILAŘOVÁ, Iveta, Libuše TRNKOVÁ, Rudolf NAVRÁTIL and Přemysl LUBAL. Copper complexes of 6-aminopurine and 6-benzylaminopurine in aqueous methanol solutions. In Ctibor Mazal, Přemysl Lubal, Miroslava Bittová. \textit{6th French - Czech ''Vltava'' Chemistry Meeting}. Brno: Masarykova univerzita, 2015, p.~45 -45. ISBN~978-80-210-7934-2.

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